Inhibition of nitric oxide synthase in the brain suppresses colonic motor activity

Daisaku Ohta, Sushil K. Sarna, Robert E. Condon, Ivan M. Lang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of inhibition of nitric oxide (NO) synthase in the brain on colonic motor activity were investigated in conscious dogs. Intracerebroventricular (ICV) infusion of N(ω)-nitro-L-arginine methyl ester (L-NAME) and N(ω)-nitro-L-arginine (L-NNA) significantly suppressed colonic motor activity. The inhibitory effects occurred 1 h after the end of the infusion and lasted for at least 4 h. This suppression was blocked by a concurrent infusion of L-arginine but not D-arginine. The suppression of colonic motor activity was not blocked by bilateral truncal vagotomy or intravenous administration of phentolamine, an α-receptor antagonist, and propranolol, a β-receptor antagonist. ICV infusion of L-NAME had no significant effect on the occurrence of giant migrating contractions in the colon. By contrast, intravenous administration of L-NAME at higher doses significantly enhanced colonic motor activity. We conclude that the inhibition of NO synthesis in the brain suppresses, whereas the inhibition of NO synthesis in peripheral neurons stimulates, colonic motor activity. The central effect may be mediated by a decrease in cerebral blood flow due to the inhibition of NO synthesis in cerebral arteries.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume270
Issue number4 33-4
StatePublished - 1996
Externally publishedYes

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Nitric Oxide Synthase
Motor Activity
NG-Nitroarginine Methyl Ester
Intraventricular Infusions
Brain
Arginine
Nitric Oxide
Intravenous Administration
Cerebrovascular Circulation
Truncal Vagotomy
Cerebral Arteries
Phentolamine
Propranolol
Colon
Inhibition (Psychology)
Dogs
Neurons

Keywords

  • central nervous system
  • cerebral blood flow
  • colonic motility
  • L-arginine

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Physiology (medical)

Cite this

Inhibition of nitric oxide synthase in the brain suppresses colonic motor activity. / Ohta, Daisaku; Sarna, Sushil K.; Condon, Robert E.; Lang, Ivan M.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 270, No. 4 33-4, 1996.

Research output: Contribution to journalArticle

Ohta, Daisaku ; Sarna, Sushil K. ; Condon, Robert E. ; Lang, Ivan M. / Inhibition of nitric oxide synthase in the brain suppresses colonic motor activity. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1996 ; Vol. 270, No. 4 33-4.
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