Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

James S. Goodwin, Jan L. Ceuppens, Martin A. Rodriguez

Research output: Contribution to journalArticle

5 Scopus citations


The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 μg/ml), carprofen (10 μg/ml) and piroxicam (10 μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)S49-S55
Issue number1 Supplement
StatePublished - Jun 1 1984
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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