Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

James Goodwin, Jan L. Ceuppens, Martin A. Rodriguez

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 μg/ml), carprofen (10 μg/ml) and piroxicam (10 μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.

Original languageEnglish (US)
JournalInflammation
Volume8
Issue number1 Supplement
DOIs
StatePublished - Jun 1984
Externally publishedYes

Fingerprint

Rheumatoid Factor
Non-Steroidal Anti-Inflammatory Agents
Anti-Inflammatory Agents
Immunoglobulin M
Pharmaceutical Preparations
Rheumatoid Arthritis
Piroxicam
Serum
Dinoprostone
Indomethacin
Lymphocytes
T-Lymphocytes
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

Cite this

Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs. / Goodwin, James; Ceuppens, Jan L.; Rodriguez, Martin A.

In: Inflammation, Vol. 8, No. 1 Supplement, 06.1984.

Research output: Contribution to journalArticle

Goodwin, James ; Ceuppens, Jan L. ; Rodriguez, Martin A. / Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs. In: Inflammation. 1984 ; Vol. 8, No. 1 Supplement.
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