Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

James S. Goodwin; Jan L. Ceuppens; Martin A. Rodriguez

doi:10.1007/BF00915712

Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

James S. Goodwin, Jan L. Ceuppens, Martin A. Rodriguez

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 μg/ml), carprofen (10 μg/ml) and piroxicam (10 μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE₂. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.

Original language	English (US)
Pages (from-to)	S49-S55
Journal	Inflammation
Volume	8
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF00915712
State	Published - Jun 1984
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/BF00915712

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title = "Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs",

abstract = "The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 μg/ml), carprofen (10 μg/ml) and piroxicam (10 μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.",

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AU - Ceuppens, Jan L.

AU - Rodriguez, Martin A.

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N2 - The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 μg/ml), carprofen (10 μg/ml) and piroxicam (10 μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.

AB - The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 μg/ml), carprofen (10 μg/ml) and piroxicam (10 μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.

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JF - Inflammation

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ER -

Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

Abstract

ASJC Scopus subject areas

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