Abstract
Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 331-344 |
| Number of pages | 14 |
| Journal | Future Virology |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2016 |
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Keywords
- antiviral
- innate immunity
- Nipah virus
- paramyxovirus
ASJC Scopus subject areas
- Virology
Cite this
Inhibition of the host antiviral response by Nipah virus : Current understanding and future perspectives. / Satterfield, Benjamin A.; Geisbert, Thomas; Mire, Chad.
In: Future Virology, Vol. 11, No. 5, 01.05.2016, p. 331-344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of the host antiviral response by Nipah virus
T2 - Current understanding and future perspectives
AU - Satterfield, Benjamin A.
AU - Geisbert, Thomas
AU - Mire, Chad
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.
AB - Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.
KW - antiviral
KW - innate immunity
KW - Nipah virus
KW - paramyxovirus
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U2 - 10.2217/fvl-2016-0027
DO - 10.2217/fvl-2016-0027
M3 - Article
VL - 11
SP - 331
EP - 344
JO - Future Virology
JF - Future Virology
SN - 1746-0794
IS - 5
ER -