Inhibition of the host antiviral response by Nipah virus: Current understanding and future perspectives

Benjamin A. Satterfield, Thomas Geisbert, Chad Mire

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.

Original languageEnglish (US)
Pages (from-to)331-344
Number of pages14
JournalFuture Virology
Volume11
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Nipah Virus
Antiviral Agents
Viral Proteins
Acute Disease
Encephalitis
Protein C
Genes
Proteins

Keywords

  • antiviral
  • innate immunity
  • Nipah virus
  • paramyxovirus

ASJC Scopus subject areas

  • Virology

Cite this

Inhibition of the host antiviral response by Nipah virus : Current understanding and future perspectives. / Satterfield, Benjamin A.; Geisbert, Thomas; Mire, Chad.

In: Future Virology, Vol. 11, No. 5, 01.05.2016, p. 331-344.

Research output: Contribution to journalArticle

@article{f3ff7561881b4ca38cd461701a70076d,
title = "Inhibition of the host antiviral response by Nipah virus: Current understanding and future perspectives",
abstract = "Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.",
keywords = "antiviral, innate immunity, Nipah virus, paramyxovirus",
author = "Satterfield, {Benjamin A.} and Thomas Geisbert and Chad Mire",
year = "2016",
month = "5",
day = "1",
doi = "10.2217/fvl-2016-0027",
language = "English (US)",
volume = "11",
pages = "331--344",
journal = "Future Virology",
issn = "1746-0794",
publisher = "Future Medicine Ltd.",
number = "5",

}

TY - JOUR

T1 - Inhibition of the host antiviral response by Nipah virus

T2 - Current understanding and future perspectives

AU - Satterfield, Benjamin A.

AU - Geisbert, Thomas

AU - Mire, Chad

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.

AB - Nipah virus (NiV) is a lethal paramyxovirus that has recently emerged as a human pathogen capable of causing acute respiratory disease and encephalitis. Like many viral pathogens, NiV has developed multiple means of antagonizing the host antiviral response. The viral proteins responsible for this antiviral inhibition are encoded in the NiV P gene and include the P, V, W and C proteins, which contain various unique and overlapping roles. This review examines the current data on inhibition of the host antiviral response for each of these proteins gathered from viral protein expression systems, in vitro data using recombinant NiV mutants and from in vivo studies using recombinant NiV mutants, as well as a future perspective regarding the direction of the field.

KW - antiviral

KW - innate immunity

KW - Nipah virus

KW - paramyxovirus

UR - http://www.scopus.com/inward/record.url?scp=84966713793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966713793&partnerID=8YFLogxK

U2 - 10.2217/fvl-2016-0027

DO - 10.2217/fvl-2016-0027

M3 - Article

AN - SCOPUS:84966713793

VL - 11

SP - 331

EP - 344

JO - Future Virology

JF - Future Virology

SN - 1746-0794

IS - 5

ER -