Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep

G. Redl, S. Abdi, L. D. Traber, R. J. Nichols, J. T. Flynn, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and Methods: There is a marked decrease of the right ventricular ejection fraction after the administration of a bolus of endotoxin to sheep. This hemodynamic response may be the result of thromboxane-mediated pulmonary hypertension. Right ventricular function was studied in an ovine model after the administration of endotoxin (1 μg/kg Escherichia coli) with and without pretreatment with OKY-046, a selective thromboxane synthetase inhibitor. Results: OKY-046 attenuated the endotoxin-induced increase in pulmonary arterial pressure and prevented the early decreases in right ventricular ejection fraction and cardiac output. However, thromboxane synthetase inhibition failed to prevent endotoxin-induced hypoxemia. The marked increase in plasma thromboxane concentrations, which is usually seen after the administration of endotoxin, was prevented by pretreating the animals with OKY-046. On the other hand, increased plasma prostacyclin concentrations were observed in sheep treated with the thromboxane synthetase inhibitor. Conclusion: This series of experiments shows that the early endotoxin-induced decrease in right ventricular ejection fraction can be alleviated by the application of OKY-046.

Original languageEnglish (US)
Pages (from-to)1294-1302
Number of pages9
JournalCritical Care Medicine
Volume19
Issue number10
StatePublished - 1991

Fingerprint

Thromboxanes
Endotoxins
Sheep
Thromboxane-A Synthase
Stroke Volume
Right Ventricular Function
Epoprostenol
Pulmonary Hypertension
Cardiac Output
Arterial Pressure
Hemodynamics
Escherichia coli
Lung
ozagrel

Keywords

  • Blood gas analysis
  • Cardiac output
  • Catheterization
  • Endotoxin
  • Hypertension
  • Oxygen consumption
  • Sheep
  • Thermodilution
  • Thromboxane
  • Vascular resistance

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Redl, G., Abdi, S., Traber, L. D., Nichols, R. J., Flynn, J. T., Herndon, D., & Traber, D. L. (1991). Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep. Critical Care Medicine, 19(10), 1294-1302.

Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep. / Redl, G.; Abdi, S.; Traber, L. D.; Nichols, R. J.; Flynn, J. T.; Herndon, David; Traber, D. L.

In: Critical Care Medicine, Vol. 19, No. 10, 1991, p. 1294-1302.

Research output: Contribution to journalArticle

Redl, G, Abdi, S, Traber, LD, Nichols, RJ, Flynn, JT, Herndon, D & Traber, DL 1991, 'Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep', Critical Care Medicine, vol. 19, no. 10, pp. 1294-1302.
Redl G, Abdi S, Traber LD, Nichols RJ, Flynn JT, Herndon D et al. Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep. Critical Care Medicine. 1991;19(10):1294-1302.
Redl, G. ; Abdi, S. ; Traber, L. D. ; Nichols, R. J. ; Flynn, J. T. ; Herndon, David ; Traber, D. L. / Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep. In: Critical Care Medicine. 1991 ; Vol. 19, No. 10. pp. 1294-1302.
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