Inhibitory action of peptide YY on gastric acid secretion

Y. S. Guo, M. Fujimura, F. Lluis, Y. Tsong, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


The purpose of this study is to investigate the effect of peptide YY (PYY) on pentagastrin-, histamine-, and bethanechol-stimulated gastric acid secretion and the possible mechanisms by which PYY inhibits gastric acid secretion. Six mongrel dogs with chronic gastric and duodenal fistulas were given an intravenous infusion of pentagastrin (0.5 μg·kg-1·h-1), histamine (18 μg·kg-1·h-1) either alone or simultaneously with intravenous PYY (100, 200, 400, pmol·kg-1·h-1). PYY (100, 200, 400 pmol·kg-1·h-1) inhibited pentagastrin-stimulated gastric acid secretion in a dose-dependent manner. PYY (400 pmol·kg-1·h-1) did not depress bethanechol-stimulated gastric acid secretion. PYY (400 pmol·kg-1·h-1) also failed to inhibit histamine-stimulated gastric acid secretion. Furthermore, PYY inhibited pentagastrin-stimulated gastric acid secretion in the face of atropine, vagotomy, or indomethacin treatment. These findings indicate that the inhibitory action of PYY on gastric acid secretion is in part independent of long and short cholinergic pathways. These findings also indicate that the inhibitory mechanism of PYY is independent of prostaglandin synthesis. Our findings are discussed in relation to previous reports regarding the effects of PYY on gastric acid secretion.

Original languageEnglish (US)
Pages (from-to)16/3
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number3
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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