Inhibitory action of peptide YY on pancreatic secretion is independent of secretin.

F. Lluis, G. Gomez, G. H. Greeley, J. C. Thompson

    Research output: Contribution to journalArticle

    Abstract

    The purpose of this study was to characterize the effect of peptide YY (PYY) on acid-stimulated pancreatic bicarbonate secretion and to determine whether PYY affects the release of secretin in response to intraduodenal infusion of acid. Six dogs were prepared with gastric and pancreatic cannulas. In study 1, graded doses of hydrochloric acid (HCl) (3, 6, 12, and 24 mEq/h) were given intraduodenally alone or in combination with intravenous PYY (400 pmol/kg.h). In study II, and ED50 of intraduodenal HCl (6 mEq/h) was given alone or in combination with graded doses of PYY (12.5, 25, 50, 100, 200, and 400 pmol/kg.h, i.v.). Bicarbonate output was significantly inhibited during PYY infusion at 200 and 400 pmol/kg.h, but plasma secretin levels were unchanged. The calculated maximal response for bicarbonate secretion (5.1 +/- 1.3 mEq/15 min) was significantly reduced by PYY (2.1 +/- 0.7 mEq/15 min). We concluded that PYY can inhibit acid-stimulated pancreatic bicarbonate secretion without affecting the release of secretin. The mechanism of the inhibitory effect of PYY on acid-stimulated pancreatic bicarbonate secretion is compatible with a noncompetitive type of inhibition.

    Original languageEnglish (US)
    Pages (from-to)88-93
    Number of pages6
    JournalBiological Signals
    Volume1
    Issue number2
    StatePublished - Mar 1992

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    Peptide YY
    Secretin
    Bicarbonates
    Acids
    Hydrochloric Acid
    Stomach
    Dogs
    Plasmas

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Lluis, F., Gomez, G., Greeley, G. H., & Thompson, J. C. (1992). Inhibitory action of peptide YY on pancreatic secretion is independent of secretin. Biological Signals, 1(2), 88-93.

    Inhibitory action of peptide YY on pancreatic secretion is independent of secretin. / Lluis, F.; Gomez, G.; Greeley, G. H.; Thompson, J. C.

    In: Biological Signals, Vol. 1, No. 2, 03.1992, p. 88-93.

    Research output: Contribution to journalArticle

    Lluis, F, Gomez, G, Greeley, GH & Thompson, JC 1992, 'Inhibitory action of peptide YY on pancreatic secretion is independent of secretin.', Biological Signals, vol. 1, no. 2, pp. 88-93.
    Lluis, F. ; Gomez, G. ; Greeley, G. H. ; Thompson, J. C. / Inhibitory action of peptide YY on pancreatic secretion is independent of secretin. In: Biological Signals. 1992 ; Vol. 1, No. 2. pp. 88-93.
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