Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls

Liangsuo Ma, Joel L. Steinberg, Kathryn Cunningham, Scott D. Lane, James M. Bjork, Harshini Neelakantan, Amanda E. Price, Ponnada A. Narayana, Thomas R. Kosten, Antoine Bechara, F. Gerard Moeller

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cocaine dependence is associated with increased impulsivity in humans. Both cocaine dependence and impulsive behavior are under the regulatory control of cortico-striatal networks. One behavioral laboratory measure of impulsivity is response inhibition (ability to withhold a prepotent response) in which altered patterns of regional brain activation during executive tasks in service of normal performance are frequently found in cocaine dependent (CD) subjects studied with functional magnetic resonance imaging (fMRI). However, little is known about aberrations in specific directional neuronal connectivity in CD subjects. The present study employed fMRI-based dynamic causal modeling (DCM) to study the effective (directional) neuronal connectivity associated with response inhibition in CD subjects, elicited under performance of a Go/NoGo task with two levels of NoGo difficulty (Easy and Hard). The performance on the Go/NoGo task was not significantly different between CD subjects and controls. The DCM analysis revealed that prefrontal-striatal connectivity was modulated (influenced) during the NoGo conditions for both groups. The effective connectivity from left (L) anterior cingulate cortex (ACC) to L caudate was similarly modulated during the Easy NoGo condition for both groups. During the Hard NoGo condition in controls, the effective connectivity from right (R) dorsolateral prefrontal cortex (DLPFC) to L caudate became more positive, and the effective connectivity from R ventrolateral prefrontal cortex (VLPFC) to L caudate became more negative. In CD subjects, the effective connectivity from L ACC to L caudate became more negative during the Hard NoGo conditions. These results indicate that during Hard NoGo trials in CD subjects, the ACC rather than DLPFC or VLPFC influenced caudate during response inhibition.

Original languageEnglish (US)
Pages (from-to)837-847
Number of pages11
JournalNeuroImage: Clinical
Volume7
DOIs
StatePublished - 2015

Fingerprint

Cocaine
Prefrontal Cortex
Impulsive Behavior
Gyrus Cinguli
Corpus Striatum
Cocaine-Related Disorders
Magnetic Resonance Imaging
Aptitude
Brain
Inhibition (Psychology)

Keywords

  • Cocaine dependence
  • Dynamic casual modeling
  • Impulsivity
  • Inhibitory control

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

Inhibitory behavioral control : A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls. / Ma, Liangsuo; Steinberg, Joel L.; Cunningham, Kathryn; Lane, Scott D.; Bjork, James M.; Neelakantan, Harshini; Price, Amanda E.; Narayana, Ponnada A.; Kosten, Thomas R.; Bechara, Antoine; Moeller, F. Gerard.

In: NeuroImage: Clinical, Vol. 7, 2015, p. 837-847.

Research output: Contribution to journalArticle

Ma, L, Steinberg, JL, Cunningham, K, Lane, SD, Bjork, JM, Neelakantan, H, Price, AE, Narayana, PA, Kosten, TR, Bechara, A & Moeller, FG 2015, 'Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls', NeuroImage: Clinical, vol. 7, pp. 837-847. https://doi.org/10.1016/j.nicl.2015.03.015
Ma, Liangsuo ; Steinberg, Joel L. ; Cunningham, Kathryn ; Lane, Scott D. ; Bjork, James M. ; Neelakantan, Harshini ; Price, Amanda E. ; Narayana, Ponnada A. ; Kosten, Thomas R. ; Bechara, Antoine ; Moeller, F. Gerard. / Inhibitory behavioral control : A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls. In: NeuroImage: Clinical. 2015 ; Vol. 7. pp. 837-847.
@article{6a49f40b719843ecaf8110c8a7d8f325,
title = "Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls",
abstract = "Cocaine dependence is associated with increased impulsivity in humans. Both cocaine dependence and impulsive behavior are under the regulatory control of cortico-striatal networks. One behavioral laboratory measure of impulsivity is response inhibition (ability to withhold a prepotent response) in which altered patterns of regional brain activation during executive tasks in service of normal performance are frequently found in cocaine dependent (CD) subjects studied with functional magnetic resonance imaging (fMRI). However, little is known about aberrations in specific directional neuronal connectivity in CD subjects. The present study employed fMRI-based dynamic causal modeling (DCM) to study the effective (directional) neuronal connectivity associated with response inhibition in CD subjects, elicited under performance of a Go/NoGo task with two levels of NoGo difficulty (Easy and Hard). The performance on the Go/NoGo task was not significantly different between CD subjects and controls. The DCM analysis revealed that prefrontal-striatal connectivity was modulated (influenced) during the NoGo conditions for both groups. The effective connectivity from left (L) anterior cingulate cortex (ACC) to L caudate was similarly modulated during the Easy NoGo condition for both groups. During the Hard NoGo condition in controls, the effective connectivity from right (R) dorsolateral prefrontal cortex (DLPFC) to L caudate became more positive, and the effective connectivity from R ventrolateral prefrontal cortex (VLPFC) to L caudate became more negative. In CD subjects, the effective connectivity from L ACC to L caudate became more negative during the Hard NoGo conditions. These results indicate that during Hard NoGo trials in CD subjects, the ACC rather than DLPFC or VLPFC influenced caudate during response inhibition.",
keywords = "Cocaine dependence, Dynamic casual modeling, Impulsivity, Inhibitory control",
author = "Liangsuo Ma and Steinberg, {Joel L.} and Kathryn Cunningham and Lane, {Scott D.} and Bjork, {James M.} and Harshini Neelakantan and Price, {Amanda E.} and Narayana, {Ponnada A.} and Kosten, {Thomas R.} and Antoine Bechara and Moeller, {F. Gerard}",
year = "2015",
doi = "10.1016/j.nicl.2015.03.015",
language = "English (US)",
volume = "7",
pages = "837--847",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Inhibitory behavioral control

T2 - A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls

AU - Ma, Liangsuo

AU - Steinberg, Joel L.

AU - Cunningham, Kathryn

AU - Lane, Scott D.

AU - Bjork, James M.

AU - Neelakantan, Harshini

AU - Price, Amanda E.

AU - Narayana, Ponnada A.

AU - Kosten, Thomas R.

AU - Bechara, Antoine

AU - Moeller, F. Gerard

PY - 2015

Y1 - 2015

N2 - Cocaine dependence is associated with increased impulsivity in humans. Both cocaine dependence and impulsive behavior are under the regulatory control of cortico-striatal networks. One behavioral laboratory measure of impulsivity is response inhibition (ability to withhold a prepotent response) in which altered patterns of regional brain activation during executive tasks in service of normal performance are frequently found in cocaine dependent (CD) subjects studied with functional magnetic resonance imaging (fMRI). However, little is known about aberrations in specific directional neuronal connectivity in CD subjects. The present study employed fMRI-based dynamic causal modeling (DCM) to study the effective (directional) neuronal connectivity associated with response inhibition in CD subjects, elicited under performance of a Go/NoGo task with two levels of NoGo difficulty (Easy and Hard). The performance on the Go/NoGo task was not significantly different between CD subjects and controls. The DCM analysis revealed that prefrontal-striatal connectivity was modulated (influenced) during the NoGo conditions for both groups. The effective connectivity from left (L) anterior cingulate cortex (ACC) to L caudate was similarly modulated during the Easy NoGo condition for both groups. During the Hard NoGo condition in controls, the effective connectivity from right (R) dorsolateral prefrontal cortex (DLPFC) to L caudate became more positive, and the effective connectivity from R ventrolateral prefrontal cortex (VLPFC) to L caudate became more negative. In CD subjects, the effective connectivity from L ACC to L caudate became more negative during the Hard NoGo conditions. These results indicate that during Hard NoGo trials in CD subjects, the ACC rather than DLPFC or VLPFC influenced caudate during response inhibition.

AB - Cocaine dependence is associated with increased impulsivity in humans. Both cocaine dependence and impulsive behavior are under the regulatory control of cortico-striatal networks. One behavioral laboratory measure of impulsivity is response inhibition (ability to withhold a prepotent response) in which altered patterns of regional brain activation during executive tasks in service of normal performance are frequently found in cocaine dependent (CD) subjects studied with functional magnetic resonance imaging (fMRI). However, little is known about aberrations in specific directional neuronal connectivity in CD subjects. The present study employed fMRI-based dynamic causal modeling (DCM) to study the effective (directional) neuronal connectivity associated with response inhibition in CD subjects, elicited under performance of a Go/NoGo task with two levels of NoGo difficulty (Easy and Hard). The performance on the Go/NoGo task was not significantly different between CD subjects and controls. The DCM analysis revealed that prefrontal-striatal connectivity was modulated (influenced) during the NoGo conditions for both groups. The effective connectivity from left (L) anterior cingulate cortex (ACC) to L caudate was similarly modulated during the Easy NoGo condition for both groups. During the Hard NoGo condition in controls, the effective connectivity from right (R) dorsolateral prefrontal cortex (DLPFC) to L caudate became more positive, and the effective connectivity from R ventrolateral prefrontal cortex (VLPFC) to L caudate became more negative. In CD subjects, the effective connectivity from L ACC to L caudate became more negative during the Hard NoGo conditions. These results indicate that during Hard NoGo trials in CD subjects, the ACC rather than DLPFC or VLPFC influenced caudate during response inhibition.

KW - Cocaine dependence

KW - Dynamic casual modeling

KW - Impulsivity

KW - Inhibitory control

UR - http://www.scopus.com/inward/record.url?scp=84926178996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926178996&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2015.03.015

DO - 10.1016/j.nicl.2015.03.015

M3 - Article

C2 - 26082893

AN - SCOPUS:84926178996

VL - 7

SP - 837

EP - 847

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -