Inhibitory effect of levocabastine on allergen-induced increase of nasal reactivity to histamine and cell influx

K. Pazdrak, P. Gorski, U. Ruta

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

For evaluation of the effect of levocabastine pretreatment on allergen-induced rhinitis symptoms, changes in nasal washings, and nasal responsiveness to histamine, 12 asymptomatic patients with documented allergic rhinitis participated in a single-blind, placebo-controlled study. Eight-day treatment with levocabastine (twice in each nostril, four times a day) caused significant reduction in nasal symptoms and inflammatory cell influx after allergen challenge, as compared with placebo administration. Levocabastine inhibited increased nasal reactivity to histamine induced by allergen provocation, as controlled by rhinitis symptoms and albumin level in nasal washings. These data reveal a high effectiveness of levocabastine in the prevention of allergen-induced rhinitis symptoms. Moreover, its inhibitory effect on inflammatory cell influx and hyperresponsiveness to histamine suggest that levocabastine is more than a simple H1-receptor antagonist.

Original languageEnglish (US)
Pages (from-to)598-601
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume48
Issue number8
StatePublished - 1993
Externally publishedYes

Fingerprint

levocabastine
Nose
Allergens
Histamine
Rhinitis
Nasal Lavage Fluid
Placebos
Histamine H1 Receptors
Albumins

Keywords

  • allergic rhinitis
  • eosinophils
  • hyperreactivity
  • levocabastine

ASJC Scopus subject areas

  • Immunology

Cite this

Inhibitory effect of levocabastine on allergen-induced increase of nasal reactivity to histamine and cell influx. / Pazdrak, K.; Gorski, P.; Ruta, U.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 48, No. 8, 1993, p. 598-601.

Research output: Contribution to journalArticle

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