Inhibitory effect of levocabastine on allergen‐induced increase of nasal reactivity to histamine and cell influx

K. Pazdrak, P. Górski, U. Ruta

    Research output: Contribution to journalArticle

    16 Scopus citations

    Abstract

    For evaluation of the effect of levocabastine pretreatment on allergen‐induced rhinitis symptoms, changes in nasal washings, and nasal responsiveness to histamine, 12 asymptomatic patients with documented allergic rhinitis participated in a single‐blind, placebo‐controlled study. Eight‐day treatment with levocabastine (twice in each nostril, four times a day) caused significant reduction in nasal symptoms and inflammatory cell influx after allergen challenge, as compared with placebo administration. Levocabastine inhibited increased nasal reactivity to histamine induced by allergen provocation, as controlled by rhinitis symptoms and albumin level in nasal washings. These data reveal a high effectiveness of levocabastine in the prevention of allergen‐induced rhinitis symptoms. Moreover, its inhibitory effect on inflammatory cell influx and hyperresponsiveness to histamine suggest that levocabastine is more than a simple H1‐receptor antagonist.

    Original languageEnglish (US)
    Pages (from-to)598-601
    Number of pages4
    JournalAllergy
    Volume48
    Issue number8
    DOIs
    StatePublished - Nov 1993

    Keywords

    • allergic rhinitis
    • eosinophils
    • hyperreactivity
    • levocabastine

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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