Inhibitory effects of ascorbic acid on growth of leukemic and lymphoma cell lines

Ting Lin Kao, Walter J. Meyer, Jan F.M. Post

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of the effects of ascorbic acid on growth of two ascorbic acid sensitive and one ascorbic acid resistant lymphocyte tumor cell lines. The cytotoxic effects of ascorbic acid on the sensitive cell lines were time and dosage dependent. Furthermore, the energy state of the ascorbic acid sensitive cells was affected by the presence of ascorbic acid before the cells became apparently non-viable, as demonstrated by 31P nuclear magnetic resonance spectroscopy. The existence of these lymphocyte cell lines with varying sensitivities to ascorbic acid may provide a useful model system for further understanding of vitamin C action on cancer cells.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalCancer Letters
Volume70
Issue number1-2
DOIs
StatePublished - Jun 15 1993

Keywords

  • ascorbic acid
  • cancer
  • cytotoxic
  • lymphocyte

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Inhibitory effects of ascorbic acid on growth of leukemic and lymphoma cell lines'. Together they form a unique fingerprint.

  • Cite this