Initiating the T Cell Response to Liver-Stage Malaria

Research output: Contribution to journalShort survey

Abstract

Kurup et al. (Cell Host Microbe 2019;25:565–577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c + cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.

Original languageEnglish (US)
JournalTrends in Parasitology
DOIs
StatePublished - Jan 1 2019

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Keywords

  • dendritic cell
  • liver
  • malaria
  • T cell

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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