Initiating the T Cell Response to Liver-Stage Malaria

Komi Gbedande; Robin Stephens

doi:10.1016/j.pt.2019.04.011

Initiating the T Cell Response to Liver-Stage Malaria

Komi Gbedande
, Robin Stephens

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Kurup et al. (Cell Host Microbe 2019;25:565–577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c⁺ cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.

Original language	English (US)
Pages (from-to)	489-490
Number of pages	2
Journal	Trends in Parasitology
Volume	35
Issue number	7
DOIs	https://doi.org/10.1016/j.pt.2019.04.011
State	Published - Jul 2019
Externally published	Yes

Keywords

T cell
dendritic cell
liver
malaria

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.pt.2019.04.011

Cite this

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title = "Initiating the T Cell Response to Liver-Stage Malaria",

abstract = "Kurup et al. (Cell Host Microbe 2019;25:565–577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c+ cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.",

keywords = "T cell, dendritic cell, liver, malaria",

author = "Komi Gbedande and Robin Stephens",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = jul,

doi = "10.1016/j.pt.2019.04.011",

language = "English (US)",

volume = "35",

pages = "489--490",

journal = "Trends in Parasitology",

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TY - JOUR

T1 - Initiating the T Cell Response to Liver-Stage Malaria

AU - Gbedande, Komi

AU - Stephens, Robin

PY - 2019/7

Y1 - 2019/7

N2 - Kurup et al. (Cell Host Microbe 2019;25:565–577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c+ cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.

AB - Kurup et al. (Cell Host Microbe 2019;25:565–577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c+ cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.

KW - T cell

KW - dendritic cell

KW - liver

KW - malaria

UR - https://www.scopus.com/pages/publications/85065882646

UR - https://www.scopus.com/pages/publications/85065882646#tab=citedBy

U2 - 10.1016/j.pt.2019.04.011

DO - 10.1016/j.pt.2019.04.011

M3 - Short survey

C2 - 31129040

AN - SCOPUS:85065882646

SN - 1471-4922

VL - 35

SP - 489

EP - 490

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 7

ER -

Initiating the T Cell Response to Liver-Stage Malaria

Abstract

Keywords

ASJC Scopus subject areas

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