Initiation of alcoholic fatty liver and hepatic inflammation with a specific recall immune response in alcohol-consuming C57Bl/6 mice

I. I. Slukvin, P. J. Boor, T. R. Jerrells

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Whether immunological responses are involved in initiation and progression of alcoholic liver disease is unclear. We describe a mouse model of alcoholic liver injury characterized by steatosis and hepatic inflammation initiated by a recall immune response. Mice immune to Listeria monocytogenes fed a liquid diet containing ethanol and challenged with viable bacteria developed steatosis within 24 h and, at a later time, elevated serum alanine aminotransferase levels, indicating more liver damage in this group. Listeria antigen also induced steatosis and increased serum alanine aminotransferase levels in immune ethanol-consuming mice. The production of tumour necrosis factor by a recall immune response in this model is a major, but not the only, component in initiation of alcoholic liver disease.

Original languageEnglish (US)
Pages (from-to)123-133
Number of pages11
JournalClinical and Experimental Immunology
Volume125
Issue number1
DOIs
StatePublished - 2001

Fingerprint

Alcoholic Fatty Liver
Alcoholic Liver Diseases
Alcohols
Inflammation
Alanine Transaminase
Liver
Ethanol
Listeria
Listeria monocytogenes
Serum
Tumor Necrosis Factor-alpha
Diet
Bacteria
Antigens
Wounds and Injuries

Keywords

  • Alcoholic liver disease
  • Hepatitis
  • Immunopathology
  • Steatosis

ASJC Scopus subject areas

  • Immunology

Cite this

Initiation of alcoholic fatty liver and hepatic inflammation with a specific recall immune response in alcohol-consuming C57Bl/6 mice. / Slukvin, I. I.; Boor, P. J.; Jerrells, T. R.

In: Clinical and Experimental Immunology, Vol. 125, No. 1, 2001, p. 123-133.

Research output: Contribution to journalArticle

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