Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)

Nadezhda E. Yun, Nathaniel S. Linde, Michele A. Zacks, Ian G. Barr, Aeron C. Hurt, Jeanon N. Smith, Natallia Dziuba, Michael R. Holbrook, Lifang Zhang, John M. Kilpatrick, C. Shane Arnold, Slobodan Paessler

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

The post-exposure therapeutic efficacy of injectable peramivir against highly pathogenic avian influenza type A H5N1 was evaluated in mice and in ferrets. Seventy to eighty percent of the H5N1-infected peramivir-treated mice, and 70% in the oseltamivir treated mice survived the 15-day study period, as compared to 36% in control (vehicle) group. Ferrets were infected intranasally with H5N1 followed by treatment with multiple doses of peramivir. In two of three trials, a statistically significant increase in survival over a 16-18 day period resulted from peramivir treatment, with improved survival of 40-64% in comparison to mock-treated or untreated animals. Injected peramivir mitigates virus-induced disease, reduces infectious virus titers in the lungs and brains and promotes survival in ferrets infected intranasally with this highly neurovirulent isolate. A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets.

Original languageEnglish (US)
Pages (from-to)198-209
Number of pages12
JournalVirology
Volume374
Issue number1
DOIs
StatePublished - Apr 25 2008

Keywords

  • Animal model
  • Antiviral agents
  • Avian influenza
  • Influenza A virus
  • Pathogenicity
  • Peramivir
  • Virulence

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Yun, N. E., Linde, N. S., Zacks, M. A., Barr, I. G., Hurt, A. C., Smith, J. N., Dziuba, N., Holbrook, M. R., Zhang, L., Kilpatrick, J. M., Arnold, C. S., & Paessler, S. (2008). Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1). Virology, 374(1), 198-209. https://doi.org/10.1016/j.virol.2007.12.029