TY - JOUR
T1 - Innate antiviral defenses in body fluids and tissues
AU - Baron, Samuel
AU - Singh, Indra
AU - Chopra, Ashok
AU - Coppenhaver, Dorian H
AU - Pan, Jingzhi
N1 - Funding Information:
Studies from our laboratory have been funded, in part, by the NIH, the MacArthur Foundation, Cooper Vision Laboratories, BioFilm, Inc., and royalties through the University of Texas. The authors wish to recognize the editorial and organization contributions of Laurie Mitchell and Lyska Morrison.
PY - 2000
Y1 - 2000
N2 - Innate, non-specific, resistance mechanisms are important barriers to pathogens, particularly delaying virus multiplication at the onset of infections. These innate defense mechanisms include a series of mechanical barriers, pre-existing inhibitory molecules, and cellular responses with antimicrobial activity. The antiviral activities of these innate inhibitors reside in a variety of partly characterized substances. This review presents the innate antiviral inhibitors in cell cultures, urine, serum, the gastrointestinal tract, the nervous system, tissues of crustaceans, and saliva. Medical adaptation of the innate antiviral defense mechanisms may be useful for prevention and treatment of viral infections. Copyright (C) 2000 Elsevier Science B.V.
AB - Innate, non-specific, resistance mechanisms are important barriers to pathogens, particularly delaying virus multiplication at the onset of infections. These innate defense mechanisms include a series of mechanical barriers, pre-existing inhibitory molecules, and cellular responses with antimicrobial activity. The antiviral activities of these innate inhibitors reside in a variety of partly characterized substances. This review presents the innate antiviral inhibitors in cell cultures, urine, serum, the gastrointestinal tract, the nervous system, tissues of crustaceans, and saliva. Medical adaptation of the innate antiviral defense mechanisms may be useful for prevention and treatment of viral infections. Copyright (C) 2000 Elsevier Science B.V.
KW - Antiviral defenses
KW - Innate antivirals
UR - http://www.scopus.com/inward/record.url?scp=0033666780&partnerID=8YFLogxK
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U2 - 10.1016/S0166-3542(00)00126-1
DO - 10.1016/S0166-3542(00)00126-1
M3 - Review article
C2 - 11114410
AN - SCOPUS:0033666780
SN - 0166-3542
VL - 48
SP - 71
EP - 89
JO - Antiviral research
JF - Antiviral research
IS - 2
ER -