Innate immune response to arenaviral infection: A focus on the highly pathogenic new world hemorrhagic arenaviruses

Takaaki Koma, Cheng Huang, Olga A. Kolokoltsova, Allan R. Brasier, Slobodan Paessler

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Arenaviruses are enveloped, negative-stranded RNA viruses that belong to the family Arenaviridae. This diverse family can be further classified into OW (Old World) and NW (New World) arenaviruses based on their antigenicity, phylogeny, and geographical distribution. Many of the NW arenaviruses are highly pathogenic viruses that cause systemic human infections characterized by hemorrhagic fever and/or neurological manifestations, constituting public health problems in their endemic regions. NW arenavirus infection induces a variety of host innate immune responses, which could contribute to the viral pathogenesis and/or influence the final outcome of virus infection in vitro and in vivo. On the other hand, NW arenaviruses have also developed several strategies to counteract the host innate immune response. We will review current knowledge regarding the interplay between the host innate immune response and NW arenavirus infection in vitro and in vivo, with emphasis on viral-encoded proteins and their effect on the type I interferon response.

Original languageEnglish (US)
Pages (from-to)4893-4903
Number of pages11
JournalJournal of Molecular Biology
Volume425
Issue number24
DOIs
StatePublished - Dec 13 2013

Keywords

  • arenavirus
  • cytokine
  • innate immunity
  • interferon
  • interferon antagonist

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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