Innate responses to pollen allergens

Koa Hosoki, Istvan Boldogh, Sanjiv Sur

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Purpose of Review: The aim of the present review was to discuss the effects of pollen components on innate immune responses. Recent Findings: Pollens contain numerous factors that can stimulate an innate immune response. These include intrinsic factors in pollens such as nicotinamide adenine dinucleotide phosphate oxidases, proteases, aqueous pollen proteins, lipids, and antigens. Each component stimulates innate immune response in a different manner. Pollen nicotinamide adenine dinucleotide phosphate oxidases induce reactive oxygen species generation and recruit neutrophils that stimulate subsequent allergic inflammation. Pollen proteases damage epithelial barrier function and increase antigen uptake. Aqueous pollen extract proteins and pollen lipids modulate dendritic cell function and induce Th2 polarization. Clinical studies have shown that modulation of innate immune response to pollens with toll-like receptor 9-and toll-like receptor 4-stimulating conjugates is well tolerated and induces clear immunological effects, but is not very effective in suppressing primary clinical endpoints of allergic inflammation. Summary: Additional research on innate immune pathways induced by pollen components is required to develop novel strategies that will mitigate the development of allergic inflammation.

Original languageEnglish (US)
Pages (from-to)79-88
Number of pages10
JournalCurrent opinion in allergy and clinical immunology
Issue number1
StatePublished - Feb 13 2015


  • Allergic inflammation
  • NADPH oxidase
  • aqueous pollen extract
  • lipid
  • reactive oxygen species

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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