Insect-Specific Viruses: A Historical Overview and Recent Developments

C. M. Roundy, S. R. Azar, Shannan Rossi, Scott Weaver, Nikos Vasilakis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae. These agents therefore present novel opportunities in the fields of viral evolution and viral/vector interaction and have tremendous potential as agents for biocontrol of vectors and or viruses of medical importance.

Original languageEnglish (US)
JournalAdvances in Virus Research
DOIs
StateAccepted/In press - 2016

Fingerprint

Insect Viruses
Togaviridae
Reoviridae
Bunyaviridae
Flaviviridae
Arboviruses
Host Specificity
Computational Biology
Culicidae
Viruses
Technology
Morbidity
Mortality

Keywords

  • Aedes
  • Arbovirus
  • Culex
  • Evolution
  • Flavivirus
  • Insect-specific virus
  • Mosquito
  • Mosquito-specific virus
  • Vaccine
  • Vector competence

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

@article{dd3fa2e1540f45ad93b16e46842dd5ae,
title = "Insect-Specific Viruses: A Historical Overview and Recent Developments",
abstract = "Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae. These agents therefore present novel opportunities in the fields of viral evolution and viral/vector interaction and have tremendous potential as agents for biocontrol of vectors and or viruses of medical importance.",
keywords = "Aedes, Arbovirus, Culex, Evolution, Flavivirus, Insect-specific virus, Mosquito, Mosquito-specific virus, Vaccine, Vector competence",
author = "Roundy, {C. M.} and Azar, {S. R.} and Shannan Rossi and Scott Weaver and Nikos Vasilakis",
year = "2016",
doi = "10.1016/bs.aivir.2016.10.001",
language = "English (US)",
journal = "Advances in Virus Research",
issn = "0065-3527",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Insect-Specific Viruses

T2 - A Historical Overview and Recent Developments

AU - Roundy, C. M.

AU - Azar, S. R.

AU - Rossi, Shannan

AU - Weaver, Scott

AU - Vasilakis, Nikos

PY - 2016

Y1 - 2016

N2 - Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae. These agents therefore present novel opportunities in the fields of viral evolution and viral/vector interaction and have tremendous potential as agents for biocontrol of vectors and or viruses of medical importance.

AB - Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae. These agents therefore present novel opportunities in the fields of viral evolution and viral/vector interaction and have tremendous potential as agents for biocontrol of vectors and or viruses of medical importance.

KW - Aedes

KW - Arbovirus

KW - Culex

KW - Evolution

KW - Flavivirus

KW - Insect-specific virus

KW - Mosquito

KW - Mosquito-specific virus

KW - Vaccine

KW - Vector competence

UR - http://www.scopus.com/inward/record.url?scp=85006713594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006713594&partnerID=8YFLogxK

U2 - 10.1016/bs.aivir.2016.10.001

DO - 10.1016/bs.aivir.2016.10.001

M3 - Article

C2 - 28433051

AN - SCOPUS:85006713594

JO - Advances in Virus Research

JF - Advances in Virus Research

SN - 0065-3527

ER -