Insect-Specific Viruses: A Historical Overview and Recent Developments

Christopher M. Roundy, Sasha R. Azar, Shannan L. Rossi, Scott C. Weaver, Nikos Vasilakis

Research output: Chapter in Book/Report/Conference proceedingChapter

53 Scopus citations


Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae. These agents therefore present novel opportunities in the fields of viral evolution and viral/vector interaction and have tremendous potential as agents for biocontrol of vectors and or viruses of medical importance.

Original languageEnglish (US)
Title of host publicationAdvances in Virus Research
PublisherAcademic Press Inc.
Number of pages28
StatePublished - 2017

Publication series

NameAdvances in Virus Research
ISSN (Print)0065-3527
ISSN (Electronic)1557-8399


  • Aedes
  • Arbovirus
  • Culex
  • Evolution
  • Flavivirus
  • Insect-specific virus
  • Mosquito
  • Mosquito-specific virus
  • Vaccine
  • Vector competence

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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