Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria

Akanni Adededji Abdoul Ibitokou, Lise Denoeud-Ndam, Sem Ezinmegnon, Rodolphe Ladékpo, Djimon Marcel Zannou, Achille Massougbodji, Pierre Marie Girard, Michel Cot, Adrian J F Luty, Nicaise Tuikue Ndam

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated the circulating plasma levels of Th1-(Interleukin-2 [IL-2], tumor necrosis factor-a [TNF-a], interferon-gamma [IFN-g]) and Th2-type (IL-4, IL-5, IL-10) cytokines in human immunodeficiency virus (HIV)-infected pregnant women living in a malaria-endemic area. We analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in HIV-infected women: cotrimoxazole prophylaxis versus mefloquine (PACOME) clinical trial who were followed until delivery. Cytokine concentrations were measured by flow cytometrybased multiplex bead array. Significantly elevated levels of IL-10 and lower levels of TNF-a were observed at delivery compared with inclusion (P = 0.005). At inclusion, the presence of circulating IFN-g, a higher CD4+ T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. At delivery, the inverse relationship between the presence of infection and circulating IFN-g persisted, although there was a positive association between the likelihood of infection and the presence of circulating TNF-a. Initiation of antiretroviral therapy was associated with elevated IL-5 production. Consistent with our own and others' observations in HIV seronegative subjects, this study shows circulating IL-10 to be a marker of infection with P. falciparum during pregnancy even in HIV-infected women, although plasma IFN-g may be a marker of anti-malarial protection in such women.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume93
Issue number2
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Fingerprint

Falciparum Malaria
Malaria
Interferon-gamma
HIV
Interleukin-10
Cytokines
Pregnancy
Tumor Necrosis Factor-alpha
Interleukin-5
Plasmodium falciparum
Pregnant Women
Infection
Mefloquine
Sulfamethoxazole Drug Combination Trimethoprim
Antimalarials
CD4 Lymphocyte Count
Interleukin-4
Interleukin-2
Clinical Trials
T-Lymphocytes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology
  • Medicine(all)

Cite this

Ibitokou, A. A. A., Denoeud-Ndam, L., Ezinmegnon, S., Ladékpo, R., Zannou, D. M., Massougbodji, A., ... Ndam, N. T. (2015). Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria. American Journal of Tropical Medicine and Hygiene, 93(2), 287-292. https://doi.org/10.4269/ajtmh.14-0653

Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria. / Ibitokou, Akanni Adededji Abdoul; Denoeud-Ndam, Lise; Ezinmegnon, Sem; Ladékpo, Rodolphe; Zannou, Djimon Marcel; Massougbodji, Achille; Girard, Pierre Marie; Cot, Michel; Luty, Adrian J F; Ndam, Nicaise Tuikue.

In: American Journal of Tropical Medicine and Hygiene, Vol. 93, No. 2, 01.08.2015, p. 287-292.

Research output: Contribution to journalArticle

Ibitokou, AAA, Denoeud-Ndam, L, Ezinmegnon, S, Ladékpo, R, Zannou, DM, Massougbodji, A, Girard, PM, Cot, M, Luty, AJF & Ndam, NT 2015, 'Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria', American Journal of Tropical Medicine and Hygiene, vol. 93, no. 2, pp. 287-292. https://doi.org/10.4269/ajtmh.14-0653
Ibitokou, Akanni Adededji Abdoul ; Denoeud-Ndam, Lise ; Ezinmegnon, Sem ; Ladékpo, Rodolphe ; Zannou, Djimon Marcel ; Massougbodji, Achille ; Girard, Pierre Marie ; Cot, Michel ; Luty, Adrian J F ; Ndam, Nicaise Tuikue. / Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria. In: American Journal of Tropical Medicine and Hygiene. 2015 ; Vol. 93, No. 2. pp. 287-292.
@article{cb6c03fc31764cacbcf15c07ab792a90,
title = "Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria",
abstract = "We investigated the circulating plasma levels of Th1-(Interleukin-2 [IL-2], tumor necrosis factor-a [TNF-a], interferon-gamma [IFN-g]) and Th2-type (IL-4, IL-5, IL-10) cytokines in human immunodeficiency virus (HIV)-infected pregnant women living in a malaria-endemic area. We analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in HIV-infected women: cotrimoxazole prophylaxis versus mefloquine (PACOME) clinical trial who were followed until delivery. Cytokine concentrations were measured by flow cytometrybased multiplex bead array. Significantly elevated levels of IL-10 and lower levels of TNF-a were observed at delivery compared with inclusion (P = 0.005). At inclusion, the presence of circulating IFN-g, a higher CD4+ T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. At delivery, the inverse relationship between the presence of infection and circulating IFN-g persisted, although there was a positive association between the likelihood of infection and the presence of circulating TNF-a. Initiation of antiretroviral therapy was associated with elevated IL-5 production. Consistent with our own and others' observations in HIV seronegative subjects, this study shows circulating IL-10 to be a marker of infection with P. falciparum during pregnancy even in HIV-infected women, although plasma IFN-g may be a marker of anti-malarial protection in such women.",
author = "Ibitokou, {Akanni Adededji Abdoul} and Lise Denoeud-Ndam and Sem Ezinmegnon and Rodolphe Lad{\'e}kpo and Zannou, {Djimon Marcel} and Achille Massougbodji and Girard, {Pierre Marie} and Michel Cot and Luty, {Adrian J F} and Ndam, {Nicaise Tuikue}",
year = "2015",
month = "8",
day = "1",
doi = "10.4269/ajtmh.14-0653",
language = "English (US)",
volume = "93",
pages = "287--292",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "2",

}

TY - JOUR

T1 - Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to plasmodium falciparum malaria

AU - Ibitokou, Akanni Adededji Abdoul

AU - Denoeud-Ndam, Lise

AU - Ezinmegnon, Sem

AU - Ladékpo, Rodolphe

AU - Zannou, Djimon Marcel

AU - Massougbodji, Achille

AU - Girard, Pierre Marie

AU - Cot, Michel

AU - Luty, Adrian J F

AU - Ndam, Nicaise Tuikue

PY - 2015/8/1

Y1 - 2015/8/1

N2 - We investigated the circulating plasma levels of Th1-(Interleukin-2 [IL-2], tumor necrosis factor-a [TNF-a], interferon-gamma [IFN-g]) and Th2-type (IL-4, IL-5, IL-10) cytokines in human immunodeficiency virus (HIV)-infected pregnant women living in a malaria-endemic area. We analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in HIV-infected women: cotrimoxazole prophylaxis versus mefloquine (PACOME) clinical trial who were followed until delivery. Cytokine concentrations were measured by flow cytometrybased multiplex bead array. Significantly elevated levels of IL-10 and lower levels of TNF-a were observed at delivery compared with inclusion (P = 0.005). At inclusion, the presence of circulating IFN-g, a higher CD4+ T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. At delivery, the inverse relationship between the presence of infection and circulating IFN-g persisted, although there was a positive association between the likelihood of infection and the presence of circulating TNF-a. Initiation of antiretroviral therapy was associated with elevated IL-5 production. Consistent with our own and others' observations in HIV seronegative subjects, this study shows circulating IL-10 to be a marker of infection with P. falciparum during pregnancy even in HIV-infected women, although plasma IFN-g may be a marker of anti-malarial protection in such women.

AB - We investigated the circulating plasma levels of Th1-(Interleukin-2 [IL-2], tumor necrosis factor-a [TNF-a], interferon-gamma [IFN-g]) and Th2-type (IL-4, IL-5, IL-10) cytokines in human immunodeficiency virus (HIV)-infected pregnant women living in a malaria-endemic area. We analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in HIV-infected women: cotrimoxazole prophylaxis versus mefloquine (PACOME) clinical trial who were followed until delivery. Cytokine concentrations were measured by flow cytometrybased multiplex bead array. Significantly elevated levels of IL-10 and lower levels of TNF-a were observed at delivery compared with inclusion (P = 0.005). At inclusion, the presence of circulating IFN-g, a higher CD4+ T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. At delivery, the inverse relationship between the presence of infection and circulating IFN-g persisted, although there was a positive association between the likelihood of infection and the presence of circulating TNF-a. Initiation of antiretroviral therapy was associated with elevated IL-5 production. Consistent with our own and others' observations in HIV seronegative subjects, this study shows circulating IL-10 to be a marker of infection with P. falciparum during pregnancy even in HIV-infected women, although plasma IFN-g may be a marker of anti-malarial protection in such women.

UR - http://www.scopus.com/inward/record.url?scp=84939240856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939240856&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.14-0653

DO - 10.4269/ajtmh.14-0653

M3 - Article

VL - 93

SP - 287

EP - 292

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 2

ER -