TY - JOUR
T1 - Insights into renal and urological complications of inflammatory bowel disease
AU - Singh, Anmol
AU - Khanna, Tejasvini
AU - Mahendru, Diksha
AU - Kahlon, Jasraj
AU - Kumar, Vikash
AU - Sohal, Aalam
AU - Yang, Juliana
N1 - Publisher Copyright:
© 2024 Baishideng Publishing Group Inc. All rights reserved.
PY - 2024/9/25
Y1 - 2024/9/25
N2 - Inflammatory bowel disease (IBD) is a chronic condition characterized by immune-mediated inflammation in the gastrointestinal tract, which follows a relapsing and remitting course. Apart from affecting the gastrointestinal tract, IBD also has extra-intestinal manifestations (EIMs). While the etiology of extrain-testinal manifestation remains unclear, it is theorized to be based on immuno-logical responses influenced by genetic factors. Renal involvement is one of the EIMs observed in ulcerative colitis and Crohn’s disease. The renal manifes-tations in IBD patients encompass a range of conditions including nephrolithiasis, amyloidosis, tubulointerstitial nephritis, glomerulonephritis (GN), obstructive pathologies, and chronic kidney disease (CKD). The incidence of CKD in IBD patients varies from 5%-15%. The decline in renal function can stem from various factors such as direct inflammatory damage to the kidneys leading to glomerular or tubular injury, or from complications like recurrent stones, amyloidosis, or GN. Additionally, nephrotoxic medications used in treating IBD, such as TNF-α inhibitors, calcineurin inhibitors, and aminosalicylates, can exacerbate the decline in renal function. Currently, there is a lack of consensus regarding these patients' screening and renal function monitoring. This review aims to assess the existing literature on the different renal complications among individuals with IBD, shedding light on their pathophysiology and management.
AB - Inflammatory bowel disease (IBD) is a chronic condition characterized by immune-mediated inflammation in the gastrointestinal tract, which follows a relapsing and remitting course. Apart from affecting the gastrointestinal tract, IBD also has extra-intestinal manifestations (EIMs). While the etiology of extrain-testinal manifestation remains unclear, it is theorized to be based on immuno-logical responses influenced by genetic factors. Renal involvement is one of the EIMs observed in ulcerative colitis and Crohn’s disease. The renal manifes-tations in IBD patients encompass a range of conditions including nephrolithiasis, amyloidosis, tubulointerstitial nephritis, glomerulonephritis (GN), obstructive pathologies, and chronic kidney disease (CKD). The incidence of CKD in IBD patients varies from 5%-15%. The decline in renal function can stem from various factors such as direct inflammatory damage to the kidneys leading to glomerular or tubular injury, or from complications like recurrent stones, amyloidosis, or GN. Additionally, nephrotoxic medications used in treating IBD, such as TNF-α inhibitors, calcineurin inhibitors, and aminosalicylates, can exacerbate the decline in renal function. Currently, there is a lack of consensus regarding these patients' screening and renal function monitoring. This review aims to assess the existing literature on the different renal complications among individuals with IBD, shedding light on their pathophysiology and management.
KW - Amyloidosis
KW - chronic kidney disease
KW - Extra-intestinal manifestations
KW - Glomerulonephritis
KW - Inflammatory bowel disease
KW - Nephrotoxicity
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U2 - 10.5527/wjn.v13.i3.96574
DO - 10.5527/wjn.v13.i3.96574
M3 - Review article
C2 - 39351187
AN - SCOPUS:85205373880
SN - 2220-6124
VL - 13
JO - World Journal of Nephrology
JF - World Journal of Nephrology
IS - 3
M1 - 96574
ER -