Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases

John A. Allen, Prem N. Yadav, Bryan L. Roth

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

5-HT2A serotonin receptors are essential molecular targets for the actions of LSD-like hallucinogens and atypical antipsychotic drugs. 5-HT2A serotonin receptors also mediate a variety of physiological processes in peripheral and central nervous systems including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. Scaffolding proteins have emerged as important regulators of 5-HT2A receptors and our recent studies suggest multiple scaffolds exist for 5-HT2A receptors including PSD95, arrestin, and caveolin. In addition, a novel interaction has emerged between p90 ribosomal S6 kinase and 5-HT2A receptors which attenuates receptor signaling. This article reviews our recent studies and emphasizes the role of scaffolding proteins and kinases in the regulation of 5-HT2A trafficking, targeting and signaling.

Original languageEnglish (US)
Pages (from-to)961-968
Number of pages8
JournalNeuropharmacology
Volume55
Issue number6
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Keywords

  • 5-HT
  • 5-Hydroxytryptamine
  • Arrestin
  • Caveolin
  • Desensitization
  • Endocytosis
  • GPCR
  • Gq
  • Internalization
  • Lipid raft
  • PDZ
  • PKC
  • PSD95
  • Post-synaptic density
  • RSK2
  • Scaffolding
  • Serotonin
  • Trafficking

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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