Insulin and glucagon production in experimental cirrhosis

A. Alwmark, A. Santos, V. Mamlok, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The release of insulin and glucagon in cirrhotic rats was examined. Rats were made cirrhotic by a combination treatment of carbon tetrachloride (CCl4) and phenobarbitone. Liver cirrhosis was verified by histologic findings. Both basal and stimulated release of insulin from isolated pancreatic islets, in vitro, were decreased significantly in cirrhotic rats, as compared with control rats. Basal, but not stimulated, levels of glucagon, in vitro, were reduced significantly in cirrhotic rats. Circulating levels of plasma insulin, glucagon, glucose, bilirubin, and amylase levels were unaffected in cirrhotic rats when compared with control rats. There were no signs of pancreatitis. The results indicated that the release of insulin and glucagon is depressed in cirrhotic rats and in rats treated with cirrhotic and CCl4. Clearance of circulating insulin and glucagon by the liver was apparently reduced, since circulating levels of insulin and glucagon were unaltered in all treated rats.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalAnnals of Surgery
Volume205
Issue number1
StatePublished - 1987

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Glucagon
Fibrosis
Insulin
Carbon Tetrachloride
Amylases
Phenobarbital
Islets of Langerhans
Bilirubin
Liver Cirrhosis
Pancreatitis
Glucose
Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Alwmark, A., Santos, A., Mamlok, V., Greeley, G. H., & Thompson, J. C. (1987). Insulin and glucagon production in experimental cirrhosis. Annals of Surgery, 205(1), 9-12.

Insulin and glucagon production in experimental cirrhosis. / Alwmark, A.; Santos, A.; Mamlok, V.; Greeley, G. H.; Thompson, J. C.

In: Annals of Surgery, Vol. 205, No. 1, 1987, p. 9-12.

Research output: Contribution to journalArticle

Alwmark, A, Santos, A, Mamlok, V, Greeley, GH & Thompson, JC 1987, 'Insulin and glucagon production in experimental cirrhosis', Annals of Surgery, vol. 205, no. 1, pp. 9-12.
Alwmark A, Santos A, Mamlok V, Greeley GH, Thompson JC. Insulin and glucagon production in experimental cirrhosis. Annals of Surgery. 1987;205(1):9-12.
Alwmark, A. ; Santos, A. ; Mamlok, V. ; Greeley, G. H. ; Thompson, J. C. / Insulin and glucagon production in experimental cirrhosis. In: Annals of Surgery. 1987 ; Vol. 205, No. 1. pp. 9-12.
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