Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury

William G. Cioffi, Dennis Gore, Loring W. Rue, Gretchen Carrougher, Hans Peter Guler, William F. McManus, Basil A. Pruitt

Research output: Contribution to journalArticle

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Abstract

Objective: The effect of insulin-like growth factor-1 (IGF-1) on energy expenditure and protein and glucose metabolism in a group of patients with thermal injury was determined. Summary Background Data: Accelerated protein catabolism is a constant feature of the hypermetabolic response to thermal injury. Insulin-like growth factor-1 has been reported to minimize protein catabolism and normalize energy expenditure in animal models of thermal injury. Methods: To determine the efficacy of IGF-1 in human burn patients, resting energy expenditure (metabolic cart), whole body protein kinetics ((N)15 Lysine), and glucose disposal (glucose tolerance test) were assessed in eight burn patients before and after a 3-day infusion of GF-1 (20 μg/kg/hr). All patients were fluid-resuscitated uneventfully and were without obvious infection at the time of study. Enteral nutrition was administered at a constant rate before and during the IGF-1 infusion. Results: Resting energy expenditure was not altered by IGF-1 (40.3 ± 2.2 vs. 39.1 ± 2.3 kcal/kg/day). However, glucose uptake was promoted, and protein oxidation decreased significantly (0.118 ± 0.029 vs. 0.087 ± 0.021 g/kg/d, p < 0.05) by IGF-1. In addition, insulin secretion, in response to a glucose challenge was blunted. Conclusions: Insulin-like growth factor-1 therapy has a beneficial effect in preserving lean body mass during severe stress conditions by minimizing the flux of amino acids toward oxidation.

Original languageEnglish (US)
Pages (from-to)310-319
Number of pages10
JournalAnnals of Surgery
Volume220
Issue number3
StatePublished - Sep 1994
Externally publishedYes

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Somatomedins
Hot Temperature
Wounds and Injuries
Energy Metabolism
Proteins
Glucose
Time and Motion Studies
Enteral Nutrition
Glucose Tolerance Test
Lysine
Animal Models
Insulin
Amino Acids
Infection

ASJC Scopus subject areas

  • Surgery

Cite this

Cioffi, W. G., Gore, D., Rue, L. W., Carrougher, G., Guler, H. P., McManus, W. F., & Pruitt, B. A. (1994). Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. Annals of Surgery, 220(3), 310-319.

Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. / Cioffi, William G.; Gore, Dennis; Rue, Loring W.; Carrougher, Gretchen; Guler, Hans Peter; McManus, William F.; Pruitt, Basil A.

In: Annals of Surgery, Vol. 220, No. 3, 09.1994, p. 310-319.

Research output: Contribution to journalArticle

Cioffi, WG, Gore, D, Rue, LW, Carrougher, G, Guler, HP, McManus, WF & Pruitt, BA 1994, 'Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury', Annals of Surgery, vol. 220, no. 3, pp. 310-319.
Cioffi WG, Gore D, Rue LW, Carrougher G, Guler HP, McManus WF et al. Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. Annals of Surgery. 1994 Sep;220(3):310-319.
Cioffi, William G. ; Gore, Dennis ; Rue, Loring W. ; Carrougher, Gretchen ; Guler, Hans Peter ; McManus, William F. ; Pruitt, Basil A. / Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. In: Annals of Surgery. 1994 ; Vol. 220, No. 3. pp. 310-319.
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