Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure

David R. Powell, Frances Liu, Bonita K. Baker, Phillip Lee, Raymond L. Hintz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Children with chronic renal failure (CRF) often fail to attain an adult height consistent with their genetic potential. The growth hormone (GH)/insulin-like growth factor (IGF)/growth plate chondrocyte axis has been intensively studied in these children to determine the basis for this growth failure. Evidence suggests that hepatic GH resistance results in deficient expression of IGF-I. However, serum IGF-I levels are usually normal and it is IGF-I action on target tissues which is inhibited, possibly by the presence of excess high-affinity IGF binding proteins (IGFBPs) in CRF serum. In this paper we evaluate the roles of IGFBP-1, -2, and -3 as growth inhibitors in CRF children. The data support a role for each of these IGFBPs as growth inhibitors. Currently, IGFBP-1 meets most criteria expected of a growth inhibitor, but IGFBP-2 and -3 will likely also meet these criteria and may well be important contributors to the growth failure of CRF. Ultimately, many or all of the six IGFBPs may be found to contribute to the excess high-affinity IGF binding sites which are a hallmark of CRF serum and are possible contributors to the growth failure of CRF children.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalPediatric Nephrology
Volume10
Issue number3
DOIs
StatePublished - Jun 1996
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Proteins
Growth Inhibitors
Chronic Kidney Failure
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 1
Somatomedins
Growth Hormone
Growth
Serum
Insulin-Like Growth Factor Binding Protein 3
Growth Plate
Chondrocytes
Binding Sites
Liver

Keywords

  • Growth
  • Growth failure
  • Growth hormone
  • Insulin-like growth factor
  • Insulin-like growth factor binding proteins
  • Renal failure

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure. / Powell, David R.; Liu, Frances; Baker, Bonita K.; Lee, Phillip; Hintz, Raymond L.

In: Pediatric Nephrology, Vol. 10, No. 3, 06.1996, p. 343-347.

Research output: Contribution to journalArticle

Powell, David R. ; Liu, Frances ; Baker, Bonita K. ; Lee, Phillip ; Hintz, Raymond L. / Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure. In: Pediatric Nephrology. 1996 ; Vol. 10, No. 3. pp. 343-347.
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