Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing

E. J. Pierre, J. Regino Perez-Polo, Alfred T. Mitchell, Sina Matin, Howard L. Foyt, David Herndon

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Many of the anabolic effects of growth hormone (GH) act through insulin- like growth factor-I (IGF-I). Systemic administration of GH in combination with IGF-I has been shown to stimulate wound reepithelialization, however, it causes hyperglycemia or hypoglycemia, respectively. We hypothesize that very low doses of IGF-I in a liposome form will have the same positive wound- healing effect when administered locally as the higher doses of GH plus IGF- I given systemically. To rest this hypothesis, rats were given a 40% TBSA full-thickness scald injury and received either placebo IGF-I (5.0 mg/kg/day, subcutaneously), IGF-I liposome (0.9 μg/kg/week, subcutaneously), or a combination of GH and IGF-I, or IGF-I liposomes for 8 weeks. GH in combination with IGF-I showed a significant increase in postburn weight. Wound reepithelialization, measured by computerized planimetry as percentage original wound area, was significantly increased in rats receiving GM plus IGF-I, GH plus IGF-I liposomes, and IGF-I liposomes when compared to sham, or IGF-I (p < 0.05). Results indicate that small doses of IGH-I, delivered in the form of liposomes, are equally effective in increasing burn wound reepithelialization as the higher doses of GH plus IGF-I, or GH plus IGF-I liposomes.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume18
Issue number4
DOIs
StatePublished - Jul 1997

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Insulin-Like Growth Factor I
Wound Healing
Growth Hormone
Genes
Liposomes
Wounds and Injuries
Anabolic Agents
Hypoglycemia
Hyperglycemia

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing. / Pierre, E. J.; Perez-Polo, J. Regino; Mitchell, Alfred T.; Matin, Sina; Foyt, Howard L.; Herndon, David.

In: Journal of Burn Care and Rehabilitation, Vol. 18, No. 4, 07.1997, p. 287-291.

Research output: Contribution to journalArticle

Pierre, E. J. ; Perez-Polo, J. Regino ; Mitchell, Alfred T. ; Matin, Sina ; Foyt, Howard L. ; Herndon, David. / Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing. In: Journal of Burn Care and Rehabilitation. 1997 ; Vol. 18, No. 4. pp. 287-291.
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