Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing

E. J. Pierre, J. Regino Perez-Polo, Alfred T. Mitchell, Sina Matin, Howard L. Foyt, David Herndon

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Many of the anabolic effects of growth hormone (GH) act through insulin- like growth factor-I (IGF-I). Systemic administration of GH in combination with IGF-I has been shown to stimulate wound reepithelialization, however, it causes hyperglycemia or hypoglycemia, respectively. We hypothesize that very low doses of IGF-I in a liposome form will have the same positive wound- healing effect when administered locally as the higher doses of GH plus IGF- I given systemically. To rest this hypothesis, rats were given a 40% TBSA full-thickness scald injury and received either placebo IGF-I (5.0 mg/kg/day, subcutaneously), IGF-I liposome (0.9 μg/kg/week, subcutaneously), or a combination of GH and IGF-I, or IGF-I liposomes for 8 weeks. GH in combination with IGF-I showed a significant increase in postburn weight. Wound reepithelialization, measured by computerized planimetry as percentage original wound area, was significantly increased in rats receiving GM plus IGF-I, GH plus IGF-I liposomes, and IGF-I liposomes when compared to sham, or IGF-I (p < 0.05). Results indicate that small doses of IGH-I, delivered in the form of liposomes, are equally effective in increasing burn wound reepithelialization as the higher doses of GH plus IGF-I, or GH plus IGF-I liposomes.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume18
Issue number4
DOIs
StatePublished - Jul 1997

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ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

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