Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens

Phillip D.K. Lee; Andrew Peacock; Martha K. Roessler; Jan Hester; John T. Reeves

doi:10.1016/0024-3205(89)90012-X

Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens

Phillip D.K. Lee, Andrew Peacock, Martha K. Roessler, Jan Hester, John T. Reeves

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Insulin-like growth factor(IGF)-I and IGF-binding activity were characterized in sera from normal, fast growing, and very fast growing chicken strains. In contrast to a previous report, specific IGF-binding activity was observed in this nonmammalian species. Age-related IGF-binding activity levels did not differ between strains. IGF-I levels were significantly higher for the normal as compared to the 2 fast growing strains. Chromatographic studies show that IGF-I is associated with acid-dissociable high MW complexes in chicken serum, and the MW patterns are similar to human serum. Circulating levels of IGF-I or IGF-binding activity do not account for accelerated somatic growth in inbred large-bodied chicken strains.

Original language	English (US)
Pages (from-to)	2465-2470
Number of pages	6
Journal	Life Sciences
Volume	45
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(89)90012-X
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(89)90012-X

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@article{59453c4d7301417fad7066e387a4108c,

title = "Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens",

abstract = "Insulin-like growth factor(IGF)-I and IGF-binding activity were characterized in sera from normal, fast growing, and very fast growing chicken strains. In contrast to a previous report, specific IGF-binding activity was observed in this nonmammalian species. Age-related IGF-binding activity levels did not differ between strains. IGF-I levels were significantly higher for the normal as compared to the 2 fast growing strains. Chromatographic studies show that IGF-I is associated with acid-dissociable high MW complexes in chicken serum, and the MW patterns are similar to human serum. Circulating levels of IGF-I or IGF-binding activity do not account for accelerated somatic growth in inbred large-bodied chicken strains.",

author = "Lee, {Phillip D.K.} and Andrew Peacock and Roessler, {Martha K.} and Jan Hester and Reeves, {John T.}",

note = "Funding Information: AcknowledQements The authors gratefully acknowledge Cheryl Pickett for technical support and Dr. Dennis Luckey for assistance with the statistical analysis. Dr. Lee was supported by grants from the University of Colorado Health Sciences Center (BRS#922) and The Children's Hospital Kempe Research Center.",

year = "1989",

doi = "10.1016/0024-3205(89)90012-X",

language = "English (US)",

volume = "45",

pages = "2465--2470",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "25",

}

TY - JOUR

T1 - Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens

AU - Lee, Phillip D.K.

AU - Peacock, Andrew

AU - Roessler, Martha K.

AU - Hester, Jan

AU - Reeves, John T.

N1 - Funding Information: AcknowledQements The authors gratefully acknowledge Cheryl Pickett for technical support and Dr. Dennis Luckey for assistance with the statistical analysis. Dr. Lee was supported by grants from the University of Colorado Health Sciences Center (BRS#922) and The Children's Hospital Kempe Research Center.

PY - 1989

Y1 - 1989

N2 - Insulin-like growth factor(IGF)-I and IGF-binding activity were characterized in sera from normal, fast growing, and very fast growing chicken strains. In contrast to a previous report, specific IGF-binding activity was observed in this nonmammalian species. Age-related IGF-binding activity levels did not differ between strains. IGF-I levels were significantly higher for the normal as compared to the 2 fast growing strains. Chromatographic studies show that IGF-I is associated with acid-dissociable high MW complexes in chicken serum, and the MW patterns are similar to human serum. Circulating levels of IGF-I or IGF-binding activity do not account for accelerated somatic growth in inbred large-bodied chicken strains.

AB - Insulin-like growth factor(IGF)-I and IGF-binding activity were characterized in sera from normal, fast growing, and very fast growing chicken strains. In contrast to a previous report, specific IGF-binding activity was observed in this nonmammalian species. Age-related IGF-binding activity levels did not differ between strains. IGF-I levels were significantly higher for the normal as compared to the 2 fast growing strains. Chromatographic studies show that IGF-I is associated with acid-dissociable high MW complexes in chicken serum, and the MW patterns are similar to human serum. Circulating levels of IGF-I or IGF-binding activity do not account for accelerated somatic growth in inbred large-bodied chicken strains.

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Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens

Abstract

ASJC Scopus subject areas

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