Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens

Phillip D.K. Lee, Andrew Peacock, Martha K. Roessler, Jan Hester, John T. Reeves

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Insulin-like growth factor(IGF)-I and IGF-binding activity were characterized in sera from normal, fast growing, and very fast growing chicken strains. In contrast to a previous report, specific IGF-binding activity was observed in this nonmammalian species. Age-related IGF-binding activity levels did not differ between strains. IGF-I levels were significantly higher for the normal as compared to the 2 fast growing strains. Chromatographic studies show that IGF-I is associated with acid-dissociable high MW complexes in chicken serum, and the MW patterns are similar to human serum. Circulating levels of IGF-I or IGF-binding activity do not account for accelerated somatic growth in inbred large-bodied chicken strains.

Original languageEnglish (US)
Pages (from-to)2465-2470
Number of pages6
JournalLife Sciences
Volume45
Issue number25
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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