Insulin-like growth factors and insulin-like growth factor binding proteins in adult patients with severe liver disease before and after orthotopic liver transplantation

Matthias M. Weber, Christoph J. Auernhammer, Phillip D.K. Lee, Dieter Engelhardt, Reinhart Zachoval

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Introduction: The liver is the main source of serum insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) and the concentration of these proteins might reflect liver function. Methods: In a retrospective longitudinal study we examined serum levels of total and free IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3 and IGFBP-6 in 21 adult patients with end-stage liver disease before and after orthotopic liver transplantation (LTX) by sensitive and specific RIAs. In each patient, the mean value of at least three measurements before and after LTX was calculated. Results: Before LTX, serum levels of total and free IGF-I, IGF-II, IGFBP-3 were low and showed a rapid and significant increase in almost all patients after successful LTX (total IGF-I: 30±7 vs. 256±30 ng/ml, p< 0.001; free IGF-I: 1.3±0.3 vs. 3.5±0.6 ng/ml, p<0.01; IGF-II: 177±28 vs. 618±30 ng/ml, p<0.001; IGFBP-3: 1,230±136 vs. 3,665±264 ng/ml, p<0.001). In contrast, IGFBP-1 was found to be high immediately before LTX, and declined to normal levels after LTX (210±40 vs. 90±15 ng/ml, p<0.01), while IGFBP-2 did not show any significant changes (1,154±296 vs. 1,303±192 ng/ml). Positive correlations were found between IGF-I, IGF-II or IGFBP-3, and serum pseudocholinesterase (R = 0.50, 0.72 and 0.61 respectively, p<0.001). Negative correlations were found between IGF-I, IGF-II or IGFBP-3, and prothrombin time (R = 0.50, 0.59 and 0.51 respectively, p<0.001). Conclusion: Patients with severe liver disease show decreased levels of total and free IGF-I, IGF-II and IGFBP-3, and increased levels of IGFBP-1. These abnormalities are promptly normalized after successful LTX. Thus, serum levels of IGF-I, IGF-II and IGFBP-3 might be useful parameters for the assessment of liver function.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalHormone Research
Volume57
Issue number3-4
DOIs
StatePublished - May 23 2002
Externally publishedYes

Keywords

  • Binding proteins
  • IGF
  • Insulin-like growth factors
  • Liver disease
  • Liver function
  • Liver transplantation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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