TY - JOUR
T1 - Insulin-like growth factors I and II in evaluation of growth retardation
AU - Rosenfeld, Ron G.
AU - Wilson, Darrell M.
AU - Lee, Phillip D.K.
AU - Hintz, Raymond L.
N1 - Funding Information:
The somatomedins constitute a family of growth hormone-dependent, insulin-like peptides, which are believed to mediate the anabolic actions of growth hormone.~ To date, two human somatomedins, insulin-like growth factors I and II, have been isolated, purified, and sequenced. 2,3 IGF-I is identical to SM-C 4, and IGF-II has major homology with a rat somatomedin, multiplication-stimulating activity. 5 Plasma concentrations of both peptides are, at least in part, controlled by growth hormone, and both peptides possess anabolic and mitogenic actions. 6 Currently, the diagnosis of GH deficiency requires documentation of the patient's inability to raise serum GH concentrations above some arbitrary level, using a variety Supported in part by Research Grants AM28229 (R.G.R.) and AM 24085 (R.L.H.) from the National Institutes of Health. Dr. Lee is a recipient of a fellowship award from the Juvenile Diabetes Foundation. Dr. Rosenfeld is the recipient of a Research Career Development Award from the National Institutes of Health. Submitted for publication Feb. 24, 1986; accepted April 10, 1986. Reprint requests: Ron G. Rosenfeld, M.D., Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305.
PY - 1986/9
Y1 - 1986/9
N2 - Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.
AB - Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.
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U2 - 10.1016/S0022-3476(86)80112-3
DO - 10.1016/S0022-3476(86)80112-3
M3 - Article
C2 - 3746530
AN - SCOPUS:0022448507
VL - 109
SP - 428
EP - 433
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -