Insulin-like growth factors I and II in evaluation of growth retardation

Ron G. Rosenfeld, Darrell M. Wilson, Phillip Lee, Raymond L. Hintz

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalThe Journal of pediatrics
Volume109
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

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Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Growth Hormone
Growth
Radioimmunoassay
Somatomedins
Reference Values

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Insulin-like growth factors I and II in evaluation of growth retardation. / Rosenfeld, Ron G.; Wilson, Darrell M.; Lee, Phillip; Hintz, Raymond L.

In: The Journal of pediatrics, Vol. 109, No. 3, 1986, p. 428-433.

Research output: Contribution to journalArticle

Rosenfeld, Ron G. ; Wilson, Darrell M. ; Lee, Phillip ; Hintz, Raymond L. / Insulin-like growth factors I and II in evaluation of growth retardation. In: The Journal of pediatrics. 1986 ; Vol. 109, No. 3. pp. 428-433.
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