Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia inducible factor-1

Keyphrases

• 3′-untranslated Region (3′-UTR) 14%
• Complementary DNA (cDNA) 14%
• Electrophoretic Mobility Shift Assay 14%
• Hepatic Iron Content 42%
• HepG2 Cells 28%
• Human Hepatic Cells 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• Insulin 100%
• Insulin Resistance 14%
• Insulin Sensitivity 14%
• Insulin Signaling Pathway 14%
• Iron Homeostasis 14%
• Iron Uptake 100%
• MRNA Level 14%
• Mutational Analysis 14%
• Non-heme Iron 28%
• Promoter Activity 14%
• Promoter Region 14%
• Protein Level 14%
• Protein Stability 14%
• Regulatory Subunit 14%
• Small Interfering RNA (siRNA) 14%
• Stable Forms 14%
• Transcription Factor 14%
• Transcriptional Level 14%
• Transcriptional Regulation 14%
• Transferrin Receptor 1 (TfR1) 100%

Biochemistry, Genetics and Molecular Biology

• 3' Untranslated Region 14%
• Electrophoretic Mobility Shift Assay 14%
• Hypoxia Inducible Factor 1 100%
• Insulin Resistance 14%
• Insulin Sensitivity 14%
• Insulin Signaling 14%
• Iron Homeostasis 14%
• Messenger RNA 14%
• Promoter Region 28%
• Signal Transduction 14%
• Small Interfering RNA 14%
• Transcription 100%
• Transcription Factors 14%
• Transfection 14%
• Transferrin 28%
• Transferrin Receptor 100%