Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein

David E. James, Robert Brown, Javier Navarro, Paul F. Pilch

Research output: Contribution to journalArticle

405 Citations (Scopus)

Abstract

At least three different glucose transport systems exist in mammalian cells. These are: (1) the constitutively active, facilitative carrier characteristic of human erythrocytes1, Hep G2 (ref. 2) cells and rat brain3; (2) the Na-dependent active transporter of kidney and small intestine4,5; and (3) the facilitative carrier of rat liver (B. Thorens and H. F. Lodish, personal communication). A fourth possible glucose transport system is the insulin-dependent carrier that may be specific to muscle and adipose tissue6. This transporter resides primarily in an intracellular compartment in resting cells from where it translocates to the cell surface upon cellular insulin exposure7-9. This raises the question of whether hormonal regulation of glucose transport is conferred by virtue of a tissue-specific signalling mechanism or a tissue-specific glucose transporter. Here we present data supporting the latter concept based upon a monoclonal antibody against the fat cell glucose transporter that identifies a unique, insulin-regulatable glucose transport protein in muscle and adipose tissue.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalNature
Volume333
Issue number6169
StatePublished - 1988
Externally publishedYes

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Facilitative Glucose Transport Proteins
Insulin
Glucose
Muscles
Adipocytes
Adipose Tissue
Communication
Monoclonal Antibodies
Kidney
Liver

ASJC Scopus subject areas

  • General

Cite this

James, D. E., Brown, R., Navarro, J., & Pilch, P. F. (1988). Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature, 333(6169), 183-185.

Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. / James, David E.; Brown, Robert; Navarro, Javier; Pilch, Paul F.

In: Nature, Vol. 333, No. 6169, 1988, p. 183-185.

Research output: Contribution to journalArticle

James, DE, Brown, R, Navarro, J & Pilch, PF 1988, 'Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein', Nature, vol. 333, no. 6169, pp. 183-185.
James, David E. ; Brown, Robert ; Navarro, Javier ; Pilch, Paul F. / Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. In: Nature. 1988 ; Vol. 333, No. 6169. pp. 183-185.
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