Insulin resistance and body fat distribution in South Asian men compared to Caucasian men

Manisha Chandalla, Ping Lin, Thanalakshmi Seenivasan, Edward H. Livingston, Peter G. Snell, Scott M. Grundy, Nicola Abate

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Objective. South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians. Research Design and Methods. Twenty-nine South Asian and 18 Caucasian non-diabetic men (age 27,±3 and 27±3 years, respectively) underwent euglycemic-hyperinsulinemic clamp for insulin sensitivity, underwater weighing for total body fat, MRI of entire abdomen for intraperitoneal (IP) and subcutaneous abdominal (SA) fat and biopsy of SA fat for adipocyte size. Results. Compared to Caucasians, in spite of similar BMI, South Asians had higher total body fat (22±6 and 15±4% of body weight; p-value<0.0001), higher SA fat (3.5±1.9 and 2.2±1.3,kg, respectively, p-value=0.004), but no differences in IP fat (1.0±0.5 and 1.0±0.7 kg, respectively, p-value=0.4). SA adipocyte, cell size was significantly higher in South Asians (3491±1393 and 1648±864 μm2; p-value=0.0001) and was inversely correlated with both glucose disposal rate (r-value= -0.57; p-value=0.0008) and plasma adiponectin concentrations (r-value=-0.71, p-value<0.0001). Adipocyte size differences persisted even when SA was matched between South Asians and Caucasians. Conclusions, Insulin resistance in young South Asian men can be observed even without Increase in IP fat mass and is related to large SA adipocytes size. Hence ethnic excess in insulin resistance in South Asians appears to be related more lto excess truncal fat and dysfunctional adipose tissue than to excess visceral fat.

Original languageEnglish (US)
Article numbere812
JournalPLoS One
Volume2
Issue number8
DOIs
StatePublished - Aug 29 2007
Externally publishedYes

Fingerprint

Body Fat Distribution
body fat distribution
insulin resistance
Insulin Resistance
Fats
Insulin
Abdominal Subcutaneous Fat
adipocytes
Adipocytes
abdominal fat
body fat
Adipose Tissue
lipids
visceral fat
adiponectin
Glucose Clamp Technique
Intra-Abdominal Fat
Adiponectin
Cell Size
abdomen

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chandalla, M., Lin, P., Seenivasan, T., Livingston, E. H., Snell, P. G., Grundy, S. M., & Abate, N. (2007). Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLoS One, 2(8), [e812]. https://doi.org/10.1371/journal.pone.0000812

Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. / Chandalla, Manisha; Lin, Ping; Seenivasan, Thanalakshmi; Livingston, Edward H.; Snell, Peter G.; Grundy, Scott M.; Abate, Nicola.

In: PLoS One, Vol. 2, No. 8, e812, 29.08.2007.

Research output: Contribution to journalArticle

Chandalla, M, Lin, P, Seenivasan, T, Livingston, EH, Snell, PG, Grundy, SM & Abate, N 2007, 'Insulin resistance and body fat distribution in South Asian men compared to Caucasian men', PLoS One, vol. 2, no. 8, e812. https://doi.org/10.1371/journal.pone.0000812
Chandalla M, Lin P, Seenivasan T, Livingston EH, Snell PG, Grundy SM et al. Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLoS One. 2007 Aug 29;2(8). e812. https://doi.org/10.1371/journal.pone.0000812
Chandalla, Manisha ; Lin, Ping ; Seenivasan, Thanalakshmi ; Livingston, Edward H. ; Snell, Peter G. ; Grundy, Scott M. ; Abate, Nicola. / Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. In: PLoS One. 2007 ; Vol. 2, No. 8.
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abstract = "Objective. South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians. Research Design and Methods. Twenty-nine South Asian and 18 Caucasian non-diabetic men (age 27,±3 and 27±3 years, respectively) underwent euglycemic-hyperinsulinemic clamp for insulin sensitivity, underwater weighing for total body fat, MRI of entire abdomen for intraperitoneal (IP) and subcutaneous abdominal (SA) fat and biopsy of SA fat for adipocyte size. Results. Compared to Caucasians, in spite of similar BMI, South Asians had higher total body fat (22±6 and 15±4{\%} of body weight; p-value<0.0001), higher SA fat (3.5±1.9 and 2.2±1.3,kg, respectively, p-value=0.004), but no differences in IP fat (1.0±0.5 and 1.0±0.7 kg, respectively, p-value=0.4). SA adipocyte, cell size was significantly higher in South Asians (3491±1393 and 1648±864 μm2; p-value=0.0001) and was inversely correlated with both glucose disposal rate (r-value= -0.57; p-value=0.0008) and plasma adiponectin concentrations (r-value=-0.71, p-value<0.0001). Adipocyte size differences persisted even when SA was matched between South Asians and Caucasians. Conclusions, Insulin resistance in young South Asian men can be observed even without Increase in IP fat mass and is related to large SA adipocytes size. Hence ethnic excess in insulin resistance in South Asians appears to be related more lto excess truncal fat and dysfunctional adipose tissue than to excess visceral fat.",
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AB - Objective. South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians. Research Design and Methods. Twenty-nine South Asian and 18 Caucasian non-diabetic men (age 27,±3 and 27±3 years, respectively) underwent euglycemic-hyperinsulinemic clamp for insulin sensitivity, underwater weighing for total body fat, MRI of entire abdomen for intraperitoneal (IP) and subcutaneous abdominal (SA) fat and biopsy of SA fat for adipocyte size. Results. Compared to Caucasians, in spite of similar BMI, South Asians had higher total body fat (22±6 and 15±4% of body weight; p-value<0.0001), higher SA fat (3.5±1.9 and 2.2±1.3,kg, respectively, p-value=0.004), but no differences in IP fat (1.0±0.5 and 1.0±0.7 kg, respectively, p-value=0.4). SA adipocyte, cell size was significantly higher in South Asians (3491±1393 and 1648±864 μm2; p-value=0.0001) and was inversely correlated with both glucose disposal rate (r-value= -0.57; p-value=0.0008) and plasma adiponectin concentrations (r-value=-0.71, p-value<0.0001). Adipocyte size differences persisted even when SA was matched between South Asians and Caucasians. Conclusions, Insulin resistance in young South Asian men can be observed even without Increase in IP fat mass and is related to large SA adipocytes size. Hence ethnic excess in insulin resistance in South Asians appears to be related more lto excess truncal fat and dysfunctional adipose tissue than to excess visceral fat.

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