Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in the regulation of aging and longevity. The balance of physiological processes controlling the rate of aging and longevity in several mouse mutants suggests the involvement of cross-talk mechanisms of regulation of the insulin/IGF1 signaling pathway vs. the ROS signaling pathways. In mice, modulation of the Ins/IGF-1 signaling pathways resulting from the Prop1df, Pit1dw and Igf1 receptor mutations exemplify the hormonal pathways associated with aging and longevity determination. These pathways are also targets of the ROS-mediated redox pathways. Similarly, the Klotho and p66Shc mutants link regulation of ROS signaling pathways to aging and longevity determination. Both of these models also display altered insulin signaling activity, a characteristic associated with longevity. The Ins/IGF-1 signaling pathway is of particular interest because of its decreased activity due to genetic manipulation vs. its responsiveness to ROS levels.

Original languageEnglish (US)
Pages (from-to)89-100
Number of pages12
JournalMolecular and Cellular Endocrinology
Volume299
Issue number1
DOIs
StatePublished - Feb 5 2009

Fingerprint

Insulin-Like Growth Factor I
Reactive Oxygen Species
Aging of materials
Insulin
Physiological Phenomena
Oxidation-Reduction
Mutation
Modulation

Keywords

  • Aging
  • Insulin/IGF-1 signaling
  • Longevity
  • ROS signaling

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. / Papaconstantinou, John.

In: Molecular and Cellular Endocrinology, Vol. 299, No. 1, 05.02.2009, p. 89-100.

Research output: Contribution to journalArticle

@article{80842b02720745f891bf22f5e96b8892,
title = "Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination",
abstract = "Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in the regulation of aging and longevity. The balance of physiological processes controlling the rate of aging and longevity in several mouse mutants suggests the involvement of cross-talk mechanisms of regulation of the insulin/IGF1 signaling pathway vs. the ROS signaling pathways. In mice, modulation of the Ins/IGF-1 signaling pathways resulting from the Prop1df, Pit1dw and Igf1 receptor mutations exemplify the hormonal pathways associated with aging and longevity determination. These pathways are also targets of the ROS-mediated redox pathways. Similarly, the Klotho and p66Shc mutants link regulation of ROS signaling pathways to aging and longevity determination. Both of these models also display altered insulin signaling activity, a characteristic associated with longevity. The Ins/IGF-1 signaling pathway is of particular interest because of its decreased activity due to genetic manipulation vs. its responsiveness to ROS levels.",
keywords = "Aging, Insulin/IGF-1 signaling, Longevity, ROS signaling",
author = "John Papaconstantinou",
year = "2009",
month = "2",
day = "5",
doi = "10.1016/j.mce.2008.11.025",
language = "English (US)",
volume = "299",
pages = "89--100",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

AU - Papaconstantinou, John

PY - 2009/2/5

Y1 - 2009/2/5

N2 - Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in the regulation of aging and longevity. The balance of physiological processes controlling the rate of aging and longevity in several mouse mutants suggests the involvement of cross-talk mechanisms of regulation of the insulin/IGF1 signaling pathway vs. the ROS signaling pathways. In mice, modulation of the Ins/IGF-1 signaling pathways resulting from the Prop1df, Pit1dw and Igf1 receptor mutations exemplify the hormonal pathways associated with aging and longevity determination. These pathways are also targets of the ROS-mediated redox pathways. Similarly, the Klotho and p66Shc mutants link regulation of ROS signaling pathways to aging and longevity determination. Both of these models also display altered insulin signaling activity, a characteristic associated with longevity. The Ins/IGF-1 signaling pathway is of particular interest because of its decreased activity due to genetic manipulation vs. its responsiveness to ROS levels.

AB - Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in the regulation of aging and longevity. The balance of physiological processes controlling the rate of aging and longevity in several mouse mutants suggests the involvement of cross-talk mechanisms of regulation of the insulin/IGF1 signaling pathway vs. the ROS signaling pathways. In mice, modulation of the Ins/IGF-1 signaling pathways resulting from the Prop1df, Pit1dw and Igf1 receptor mutations exemplify the hormonal pathways associated with aging and longevity determination. These pathways are also targets of the ROS-mediated redox pathways. Similarly, the Klotho and p66Shc mutants link regulation of ROS signaling pathways to aging and longevity determination. Both of these models also display altered insulin signaling activity, a characteristic associated with longevity. The Ins/IGF-1 signaling pathway is of particular interest because of its decreased activity due to genetic manipulation vs. its responsiveness to ROS levels.

KW - Aging

KW - Insulin/IGF-1 signaling

KW - Longevity

KW - ROS signaling

UR - http://www.scopus.com/inward/record.url?scp=58349097705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58349097705&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2008.11.025

DO - 10.1016/j.mce.2008.11.025

M3 - Article

C2 - 19103250

AN - SCOPUS:58349097705

VL - 299

SP - 89

EP - 100

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1

ER -