Insulinotropic and gastrin-releasing action of gastrin-releasing peptide (GRP)

George H. Greeley, James C. Thompson

    Research output: Contribution to journalArticlepeer-review

    62 Scopus citations

    Abstract

    The effect of intravenous administration of gastrin-releasing peptide (GRP) on serum gastrin and insulin levels was studied in ad libitum fed and 24-h fasted rats. Administration of GRP (55 μg/kg body weight) caused a significant (P < 0.05) elevation in serum gastrin levels at 10, 30, 60, and 120 min in the rats fed ad libitum, whereas in the fasted rats, gastrin levels rose significantly only at 10 min. GRP did not cause insulin release in fasted rats, but in the fed rats, it led to a significant elevation in serum insulin levels at 10 and 30 min, in comparison to controls. GRP appears to have an insulinotropic action in addition to a gastrin-releasing effect.

    Original languageEnglish (US)
    Pages (from-to)97-103
    Number of pages7
    JournalRegulatory Peptides
    Volume8
    Issue number2
    DOIs
    StatePublished - Mar 1984

    Keywords

    • GRP
    • fasted rats
    • fed rats
    • gastrin
    • insulin

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Clinical Biochemistry
    • Cellular and Molecular Neuroscience

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