Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection

Keyphrases

• SARS-CoV-2 Infection 100%
• Multi-omics Analysis 100%
• Antiviral Host Factors 100%
• KLF5 100%
• Viral 66%
• Virus-host Interactions 66%
• DAZAP2 66%
• Transcription Factor 33%
• Virus Proteins 33%
• RNA-protein Complex 33%
• Antiviral Activity 33%
• Molecular Characterization 33%
• Genetic Variation 33%
• Viral Entry 33%
• Cohesin Complex 33%
• Three-dimensional (3D) 33%
• Knowledge Gaps 33%
• Host Factors 33%
• Chromatin Organization 33%
• Vacuolar H+-ATPase (V-ATPase) 33%
• Severe Symptoms 33%
• Coagulation System 33%
• Genome-wide Association Study 33%
• Omics Data 33%
• Knockout Cells 33%
• Screening Analysis 33%
• Sphingolipid Metabolism 33%
• Antiviral Pathways 33%
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 33%
• Countermeasure Strategy 33%
• Single-cell RNA Sequencing (scRNA-seq) 33%
• Endosomal Sorting Complex Required for Transport (ESCRT) 33%
• Viral Host Factor 33%
• COVID-19 Patients 33%
• Integrative Analysis 33%
• COVID-19 Severity 33%
• CRISPR Interference (CRISPRi) 33%
• RNA Interactome 33%
• Host Antiviral Factor 33%
• Dropout Screen 33%
• N-glycosylation Pathway 33%

Biochemistry, Genetics and Molecular Biology

• SARS Coronavirus 100%
• KLF5 100%
• Tamsulosin 100%
• CRISPR 66%
• Viral Protein 33%
• RNA Sequencing 33%
• RNA 33%
• Genetic Variation 33%
• Virus Entry 33%
• Coagulation System 33%
• Cohesin 33%
• Glycosylation 33%
• V-ATPase 33%
• Genome-Wide Association Study 33%
• Sphingolipid Metabolism 33%
• Interactome 33%
• Endosomal Sorting Complex Required Transport 33%