Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs

L. M. Cranmer, A. Langat, K. Ronen, C. J. McGrath, S. LaCourse, J. Pintye, B. Odeny, B. Singa, A. Katana, L. Nganga, J. Kinuthia, G. John-Stewart

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS : As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-tosize sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region. The World Health Organization (WHO) TB symptom screen was administered to HIV-infected mothers, and associations with infant cofactors were determined. R E SULT S : Among 498 HIV-infected mothers, 165 (33%) had a positive TB symptom screen. Positive maternal TB symptom screen was associated with prior TB (P 0.04). Women with a positive TB symptom screen were more likely to have an infant with HIV infection (P 0.02) and non-specific TB symptoms, including cough (P 0.003), fever (P 0.05), and difficulty breathing (P 0.01). TB exposure was reported by 11% of the women, and 15% of the TBexposed women received isoniazid preventive therapy. CONCLUS IONS : Postpartum HIV-infected mothers frequently had a positive TB symptom screen. Mothers with a positive TB symptom screen were more likely to have infants with HIV or non-specific TB symptoms. Integration of maternal TB screening and prevention into PMTCT programs may improve maternal and infant outcomes.

Original languageEnglish (US)
Pages (from-to)256-262
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2017

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Tuberculosis
Mothers
HIV
Kenya
Isoniazid
Program Evaluation
Virus Diseases
Cough
Postpartum Period
Immunization
Respiration
Fever

Keywords

  • HIV
  • PMTCT
  • Tuberculosis screening

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Cranmer, L. M., Langat, A., Ronen, K., McGrath, C. J., LaCourse, S., Pintye, J., ... John-Stewart, G. (2017). Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs. International Journal of Tuberculosis and Lung Disease, 21(3), 256-262. https://doi.org/10.5588/ijtld.16.0478

Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs. / Cranmer, L. M.; Langat, A.; Ronen, K.; McGrath, C. J.; LaCourse, S.; Pintye, J.; Odeny, B.; Singa, B.; Katana, A.; Nganga, L.; Kinuthia, J.; John-Stewart, G.

In: International Journal of Tuberculosis and Lung Disease, Vol. 21, No. 3, 01.03.2017, p. 256-262.

Research output: Contribution to journalArticle

Cranmer, LM, Langat, A, Ronen, K, McGrath, CJ, LaCourse, S, Pintye, J, Odeny, B, Singa, B, Katana, A, Nganga, L, Kinuthia, J & John-Stewart, G 2017, 'Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs', International Journal of Tuberculosis and Lung Disease, vol. 21, no. 3, pp. 256-262. https://doi.org/10.5588/ijtld.16.0478
Cranmer, L. M. ; Langat, A. ; Ronen, K. ; McGrath, C. J. ; LaCourse, S. ; Pintye, J. ; Odeny, B. ; Singa, B. ; Katana, A. ; Nganga, L. ; Kinuthia, J. ; John-Stewart, G. / Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs. In: International Journal of Tuberculosis and Lung Disease. 2017 ; Vol. 21, No. 3. pp. 256-262.
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