Integrative biological analysis for neuropsychopharmacology

Mark R. Emmett, Roger A. Kroes, Joseph R. Moskal, Charles A. Conrad, Waldemar Priebe, Fernanda Laezza, Anke Meyer-Baese, Carol L. Nilsson

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Although advances in psychotherapy have been made in recent years, drug discovery for brain diseases such as schizophrenia and mood disorders has stagnated. The need for new biomarkers and validated therapeutic targets in the field of neuropsychopharmacology is widely unmet. The brain is the most complex part of human anatomy from the standpoint of number and types of cells, their interconnections, and circuitry. To better meet patient needs, improved methods to approach brain studies by understanding functional networks that interact with the genome are being developed. The integrated biological approaches - proteomics, transcriptomics, metabolomics, and glycomics - have a strong record in several areas of biomedicine, including neurochemistry and neuro-oncology. Published applications of an integrated approach to projects of neurological, psychiatric, and pharmacological natures are still few but show promise to provide deep biological knowledge derived from cells, animal models, and clinical materials. Future studes that yield insights based on integrated analyses promise to deliver new therapeutic targets and biomarkers for personalized medicine.

Original languageEnglish (US)
Pages (from-to)5-23
Number of pages19
JournalNeuropsychopharmacology
Volume39
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • neuro-oncology
  • neurological disease
  • psychiatric disorder
  • systems biology

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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    Emmett, M. R., Kroes, R. A., Moskal, J. R., Conrad, C. A., Priebe, W., Laezza, F., Meyer-Baese, A., & Nilsson, C. L. (2014). Integrative biological analysis for neuropsychopharmacology. Neuropsychopharmacology, 39(1), 5-23. https://doi.org/10.1038/npp.2013.156