Integrator: Surprisingly diverse functions in gene expression

David Baillat, Eric J. Wagner

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

The discovery of the metazoan-specific Integrator (INT) complex represented a breakthrough in our understanding of noncoding U-rich small nuclear RNA (UsnRNA) maturation and has triggered a reevaluation of their biosynthesis mechanism. In the decade since, significant progress has been made in understanding the details of its recruitment, specificity, and assembly. While some discrepancies remain on how it interacts with the C-terminal domain (CTD) of the RNA polymerase II (RNAPII) and the details of its recruitment to UsnRNA genes, preliminary models have emerged. Recent provocative studies now implicate INT in the regulation of protein-coding gene transcription initiation and RNAPII pause-release, thereby broadening the scope of INT functions in gene expression regulation. We discuss the implications of these findings while putting them into the context of what is understood about INT function at UsnRNA genes.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalTrends in biochemical sciences
Volume40
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Integrator
  • Pause-release
  • RNAPII CTD
  • Transcriptional activation
  • UsnRNA processing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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