Integrin Regulators in Neutrophils

Sunitha Pulikkot, Liang Hu, Yunfeng Chen, Hao Sun, Zhichao Fan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Neutrophils are the most abundant leukocytes in humans and are critical for innate immunity and inflammation. Integrins are critical for neutrophil functions, especially for their recruitment to sites of inflammation or infections. Integrin conformational changes during activation have been heavily investigated but are still not fully understood. Many regulators, such as talin, Rap1-interacting adaptor molecule (RIAM), Rap1, and kindlin, are critical for integrin activation and might be potential targets for integrin-regulating drugs in treating inflammatory diseases. In this review, we outline integrin activation regulators in neutrophils with a focus on the above critical regulators, as well as newly discovered modulators that are involved in integrin activation.

Original languageEnglish (US)
Article number2025
JournalCells
Volume11
Issue number13
DOIs
StatePublished - Jul 1 2022

Keywords

  • Integrins
  • Kindlin
  • Neutrophils
  • RIAM
  • Rap1
  • Talin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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