Intellectual development in 12-year-old children treated for phenylketonuria

C. G. Azen, R. Koch, E. G. Friedman, S. Berlow, J. Coldwell, W. Krause, Reuben Matalon, E. McCabe, M. O'Flynn, R. Peterson, B. Rouse, C. R. Scott, B. Sigman, D. Valle, R. Warner

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Intelligence and achievement test scores were evaluated for 95 12-year-old children with phenylketonuria who had begun dietary therapy during the neonatal period. Dietary control of blood phenylalanine below 900 μmol/L was maintained beyond age 10 years in 23 children; 72 others had blood phenylalanine persistently above that level at ages ranging from 18 months to 10 years. Test scores at age 12 years were negatively correlated with the age at initiation of diet and with blood phenylalanine levels from ages 4 to 10 years, and positively correlated with parent IQ scores and the age at loss of dietary control. Children who maintained phenylalanine levels below 900 μmol/L beyond age 10 years showed no deficits in test scores, except for arithmetic, the scores of which declined between ages 6 and 12 years in 90% of the children in this study. These data strongly support a recommendation that dietary restriction of phenylalanine should be maintained through adolescence.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume145
Issue number1
StatePublished - 1991
Externally publishedYes

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Phenylketonurias
Phenylalanine
Intelligence Tests
Diet

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Azen, C. G., Koch, R., Friedman, E. G., Berlow, S., Coldwell, J., Krause, W., ... Warner, R. (1991). Intellectual development in 12-year-old children treated for phenylketonuria. American Journal of Diseases of Children, 145(1), 35-39.

Intellectual development in 12-year-old children treated for phenylketonuria. / Azen, C. G.; Koch, R.; Friedman, E. G.; Berlow, S.; Coldwell, J.; Krause, W.; Matalon, Reuben; McCabe, E.; O'Flynn, M.; Peterson, R.; Rouse, B.; Scott, C. R.; Sigman, B.; Valle, D.; Warner, R.

In: American Journal of Diseases of Children, Vol. 145, No. 1, 1991, p. 35-39.

Research output: Contribution to journalArticle

Azen, CG, Koch, R, Friedman, EG, Berlow, S, Coldwell, J, Krause, W, Matalon, R, McCabe, E, O'Flynn, M, Peterson, R, Rouse, B, Scott, CR, Sigman, B, Valle, D & Warner, R 1991, 'Intellectual development in 12-year-old children treated for phenylketonuria', American Journal of Diseases of Children, vol. 145, no. 1, pp. 35-39.
Azen CG, Koch R, Friedman EG, Berlow S, Coldwell J, Krause W et al. Intellectual development in 12-year-old children treated for phenylketonuria. American Journal of Diseases of Children. 1991;145(1):35-39.
Azen, C. G. ; Koch, R. ; Friedman, E. G. ; Berlow, S. ; Coldwell, J. ; Krause, W. ; Matalon, Reuben ; McCabe, E. ; O'Flynn, M. ; Peterson, R. ; Rouse, B. ; Scott, C. R. ; Sigman, B. ; Valle, D. ; Warner, R. / Intellectual development in 12-year-old children treated for phenylketonuria. In: American Journal of Diseases of Children. 1991 ; Vol. 145, No. 1. pp. 35-39.
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AU - Krause, W.

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AU - Warner, R.

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