Intensity of infection in AIDS-associated cryptosporidiosis

Richard W. Goodgame, Robert M. Genta, A. Clinton White, Cynthia L. Chappell

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

A fluorescent monoclonal anti-Cryptosporidium antibody was used to count the oocysts in stools of 12 AIDS patients with chronic cryptosporidiosis. Oocyst excretion was present throughout the day in all 12 patients. Stool-to-stool variation in oocyst concentration was within one order of magnitude. Small variations were also found in daily mean oocyst concentration and total daily oocyst excretion in 3 patients who had multiple 24-h stool collections. However, there was a large patient-to-patient variation in mean oocyst concentration (from <5.0 × 103 to 9.2 × 105 oocysts/mL) and 24-h total oocyst excretion (from <6.0 × 106 to 1.2 × 109 oocysts/day). There was a significant correlation between oocyst excretion and numbers of Cryptosporidium organisms seen on small bowel biopsy. Oocyst excretion was reduced in 4 patients treated with paromomycin, but diarrhea improved only in the 2 patients with high initial oocyst excretion.

Original languageEnglish
Pages (from-to)704-709
Number of pages6
JournalJournal of Infectious Diseases
Volume167
Issue number3
StatePublished - Mar 1993
Externally publishedYes

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Cryptosporidiosis
Oocysts
Acquired Immunodeficiency Syndrome
Infection
Cryptosporidium
Paromomycin
Anti-Idiotypic Antibodies
Diarrhea

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Goodgame, R. W., Genta, R. M., White, A. C., & Chappell, C. L. (1993). Intensity of infection in AIDS-associated cryptosporidiosis. Journal of Infectious Diseases, 167(3), 704-709.

Intensity of infection in AIDS-associated cryptosporidiosis. / Goodgame, Richard W.; Genta, Robert M.; White, A. Clinton; Chappell, Cynthia L.

In: Journal of Infectious Diseases, Vol. 167, No. 3, 03.1993, p. 704-709.

Research output: Contribution to journalArticle

Goodgame, RW, Genta, RM, White, AC & Chappell, CL 1993, 'Intensity of infection in AIDS-associated cryptosporidiosis', Journal of Infectious Diseases, vol. 167, no. 3, pp. 704-709.
Goodgame, Richard W. ; Genta, Robert M. ; White, A. Clinton ; Chappell, Cynthia L. / Intensity of infection in AIDS-associated cryptosporidiosis. In: Journal of Infectious Diseases. 1993 ; Vol. 167, No. 3. pp. 704-709.
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