Intensity of infection in AIDS-related intestinal microsporidiosis

Richard W. Goodgame, Charles Stager, Brian Marcantel, Eduardo Alcocer, Ana Marie Segura

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


To quantify intensity of infection in AIDS-related microsporidiosis, 20 patients with known microsporidiosis submitted stools for quantitative spore counts after staining with a calcofluor white stain. Nine patients collected stools for 24 h, for assessment of daily spore excretion, stool-to-stool variation in spore excretion, and patient-to-patient variation in intensity of infection. The number of organisms seen in small bowel biopsy specimens from 7 patients was compared with quantitative fecal spore excretion. Fecal spore concentration in 20 patients ranged from 4.5 x 105 to 4.4 x 108 spores/mL of stool. There was a strong correlation between fecal spore excretion and duodenal biopsy spore counts (r = .82; P < .024). Microsporidium infections in AIDS patients can be quantified by counting spores in stool and by small bowel biopsy. Variations in intensity of infection from patient to patient are great and are similar to those in AIDS- related Cryptosporidium infection.

Original languageEnglish (US)
Pages (from-to)929-932
Number of pages4
JournalJournal of Infectious Diseases
Issue number3
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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