Interaction of chikungunya virus with the mosquito vector

Konstantin Tsetsarkin; Lark L. Coffey; Scott C. Weaver

doi:10.1007/978-3-319-42958-8_7

Interaction of chikungunya virus with the mosquito vector

Konstantin Tsetsarkin, Lark L. Coffey, Scott C. Weaver

Microbiology And Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) transmitted by mosquito vectors. Specific aspects of CHIKV interaction with its vectors play a significant role in virus biology, and therefore have a direct influence on the process of CHIKV emergence and the resultant dynamics of outbreaks. The focus of this review is to summarize current understanding of the intrinsic (determined by virus and mosquito genetics) and extrinsic (environmental) factors as well as the complex interplay between them that governs the process of the CHIKVvector interaction, determines CHIKV transmission dynamics and ultimately the process of disease emergence. Recent advances in CHIKV control through vector manipulation are also discussed.

Original language	English (US)
Title of host publication	Chikungunya Virus
Subtitle of host publication	Advances in Biology, Pathogenesis, and Treatment
Publisher	Springer International Publishing
Pages	99-126
Number of pages	28
ISBN (Electronic)	9783319429588
ISBN (Print)	9783319429564
DOIs	https://doi.org/10.1007/978-3-319-42958-8_7
State	Published - Jan 1 2016

Keywords

Aedes aegypti
Aedes albopictus
E1 and E2 glycoproteins mutations
Transmission cycle

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

Access to Document

10.1007/978-3-319-42958-8_7

Cite this

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AU - Coffey, Lark L.

AU - Weaver, Scott C.

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AB - Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) transmitted by mosquito vectors. Specific aspects of CHIKV interaction with its vectors play a significant role in virus biology, and therefore have a direct influence on the process of CHIKV emergence and the resultant dynamics of outbreaks. The focus of this review is to summarize current understanding of the intrinsic (determined by virus and mosquito genetics) and extrinsic (environmental) factors as well as the complex interplay between them that governs the process of the CHIKVvector interaction, determines CHIKV transmission dynamics and ultimately the process of disease emergence. Recent advances in CHIKV control through vector manipulation are also discussed.

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KW - Aedes albopictus

KW - E1 and E2 glycoproteins mutations

KW - Transmission cycle

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Interaction of chikungunya virus with the mosquito vector

Abstract

Keywords

ASJC Scopus subject areas

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