Interaction of nicotine and a H2-receptor antagonist, famotidine, on gastrin and chromogranin A expression

Guillermo Gomez, Vidyavathi Udupi, George H. Greeley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study is to examine the effect of nicotine on famotidine-induced hypergastrinemia in the rat. In addition, the effects of nicotine on gene expression for gastrin and chromogranin A (CGA) in the stomach were examined. Famotidine treatment alone (20 mg/kg, 2x/day for 14 days) increased serum gastrin levels significantly (P < 0.05) but not antral levels of gastrin mRNA and peptide. Nicotine treatment (12 mg/kg/d) alone did not affect serum gastrin levels; however, nicotine potentiated the hypergastrinemic action of famotidine. The hypergastrinemic action of nicotine was not mediated by a downregulation of stomach somatostatin (SRIF) since stomach SRIF mRNA levels were unaffected by nicotine treatment. Administration of nicotine and famotidine also upregulated stomach CGA gene expression (i.e., mRNA and protein levels) significantly.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalRegulatory Peptides
Volume69
Issue number2
DOIs
StatePublished - Mar 26 1997

Fingerprint

Famotidine
Chromogranin A
Histamine H2 Receptors
Gastrins
Nicotine
Stomach
Gene expression
Messenger RNA
Gene Expression
Somatostatin
Serum
Rats
Down-Regulation
Peptides

Keywords

  • CGA
  • Gut
  • Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Interaction of nicotine and a H2-receptor antagonist, famotidine, on gastrin and chromogranin A expression. / Gomez, Guillermo; Udupi, Vidyavathi; Greeley, George H.

In: Regulatory Peptides, Vol. 69, No. 2, 26.03.1997, p. 77-82.

Research output: Contribution to journalArticle

Gomez, Guillermo ; Udupi, Vidyavathi ; Greeley, George H. / Interaction of nicotine and a H2-receptor antagonist, famotidine, on gastrin and chromogranin A expression. In: Regulatory Peptides. 1997 ; Vol. 69, No. 2. pp. 77-82.
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