Interaction of radiation with microparticles for enhancement of drug delivery in tumors

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Various promising anti-cancer drugs have been proposed for cancer therapy for the past two decades. However, limited success has been achieved in cancer therapy. Slow diffusion of the drugs (especially macromolecular ones with molecular weight greater than 5,000) in the interstitium and their poor penetration through tumor vasculature and cancer cell membrane explain partially this paradox. A novel technique is proposed to alter properties of these barriers and enhance drug delivery in cancer cells with minimal damage to normal tissues. This technique is based on interaction of exogenous nano- and microparticles selectively delivered in tumor blood vessels with radiation resulting in cavitation near the particles. Cavitation may perforate tumor blood vessels and cancer cell membranes and induce microconvection in the interstitium. This yields increased penetration of anti-cancer drugs from blood into cancer cells. Preliminary experiments were performed with various tissues (liver, muscle, kidney, lung) to demonstrate penetration and migration of particles and macromolecules in the interstitium upon irradiation by laser pulses or ultrasound. Q-switched Nd:YAG and Alexandrite laser pulses and ultrasound with the frequency of 50 kHz were used in these studies. Particle penetration was 30-180 μm upon 10-min irradiation by laser pulses or ultrasound that is comparable to the average distance of 200 μm between tumor capillaries. Considerable enhancement of delivery of FITC-dextran (M.W. = 12,000) simulating macromolecular anti-cancer drugs in these tissues was obtained. Our results suggest that the proposed technique can potentially enhance delivery of anti-cancer drugs in tumors of various organs.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages166-176
Number of pages11
Volume3601
StatePublished - 1999
EventProceedings of the 1999 Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical - San Jose, CA, USA
Duration: Jan 24 1999Jan 27 1999

Other

OtherProceedings of the 1999 Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
CitySan Jose, CA, USA
Period1/24/991/27/99

Fingerprint

microparticles
Drug delivery
Tumors
delivery
drugs
tumors
cancer
Radiation
augmentation
radiation
Laser pulses
Ultrasonics
Blood vessels
Cell membranes
Tissue
Cavitation
interactions
penetration
Cells
Irradiation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Esenaliev, R. (1999). Interaction of radiation with microparticles for enhancement of drug delivery in tumors. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3601, pp. 166-176). Society of Photo-Optical Instrumentation Engineers.

Interaction of radiation with microparticles for enhancement of drug delivery in tumors. / Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3601 Society of Photo-Optical Instrumentation Engineers, 1999. p. 166-176.

Research output: Chapter in Book/Report/Conference proceedingChapter

Esenaliev, R 1999, Interaction of radiation with microparticles for enhancement of drug delivery in tumors. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3601, Society of Photo-Optical Instrumentation Engineers, pp. 166-176, Proceedings of the 1999 Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, San Jose, CA, USA, 1/24/99.
Esenaliev R. Interaction of radiation with microparticles for enhancement of drug delivery in tumors. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3601. Society of Photo-Optical Instrumentation Engineers. 1999. p. 166-176
Esenaliev, Rinat. / Interaction of radiation with microparticles for enhancement of drug delivery in tumors. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3601 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 166-176
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