Interaction of silicate dust with erythrocyte ghost membrane: In vitro studies

S. V. Singh, B. Das, M Khan, Q. Rahman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Composition of the erythrocyte ghost membrane obtained from slate-dust-lysed and hypotonically lysed erythrocytes were compared in vitro. The protein and cholesterol contents were unaltered, whilst phospholipid and glycosamine contents decreased significantly in the slate-dust-lysed preparation of erythrocyte ghost membrane. Na+,K+-ATPase activity remained unchanged, whilst acetylcholinesterase activity was decreased slightly by slate dust treatment. Further, binding of silicic acid, dissolving out of slate dust, was observed with a component of erythrocyte ghost membrane protein having molecular weight around 90000 daltons. The significance of the findings is discussed.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalJournal of Applied Toxicology
Volume4
Issue number5
StatePublished - 1984
Externally publishedYes

Fingerprint

Slate
Silicates
Erythrocyte Membrane
Dust
Membranes
Silicic Acid
Acetylcholinesterase
Adenosine Triphosphatases
Phospholipids
Membrane Proteins
Molecular weight
Cholesterol
In Vitro Techniques
Erythrocytes
Molecular Weight
Chemical analysis
Proteins

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Interaction of silicate dust with erythrocyte ghost membrane : In vitro studies. / Singh, S. V.; Das, B.; Khan, M; Rahman, Q.

In: Journal of Applied Toxicology, Vol. 4, No. 5, 1984, p. 236-240.

Research output: Contribution to journalArticle

Singh, S. V. ; Das, B. ; Khan, M ; Rahman, Q. / Interaction of silicate dust with erythrocyte ghost membrane : In vitro studies. In: Journal of Applied Toxicology. 1984 ; Vol. 4, No. 5. pp. 236-240.
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