Interaction of silicate dust with erythrocyte ghost membrane: In vitro studies

S. V. Singh, B. Das, M Khan, Q. Rahman

Research output: Contribution to journalArticle

2 Scopus citations


Composition of the erythrocyte ghost membrane obtained from slate-dust-lysed and hypotonically lysed erythrocytes were compared in vitro. The protein and cholesterol contents were unaltered, whilst phospholipid and glycosamine contents decreased significantly in the slate-dust-lysed preparation of erythrocyte ghost membrane. Na+,K+-ATPase activity remained unchanged, whilst acetylcholinesterase activity was decreased slightly by slate dust treatment. Further, binding of silicic acid, dissolving out of slate dust, was observed with a component of erythrocyte ghost membrane protein having molecular weight around 90000 daltons. The significance of the findings is discussed.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalJournal of Applied Toxicology
Issue number5
StatePublished - 1984
Externally publishedYes


ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

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