Interactions between nutritional factors and drug biotransformations in man

A. P. Alvares, Karl Anderson, A. H. Conney, A. Kappas

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three normal volunteers were fed a low carbohydrate - high protein diet for 2 wk, followed by a high carbohydrate - low protein diet for the following 2 wk. At the end of each test diet period, the plasma elmination rates of antipyrine and theophylline were determined. The mean plasma half life for antipyrine was 17.5 hr on the high carbohydrate - low protein diet and 9.2 hr on the low carbohydrate - high protein diet. The mean plasma half life for theophylline was 8.9 hr on the high carbohydrate - low protein diet and 5.9 hr on the low carbohydrate - high protein diet. These data demonstrate marked influence of dietary carbohydrate and/or protein ingestion on oxidative biotransformation of drugs in man.

Original languageEnglish (US)
Pages (from-to)2501-2504
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number7
StatePublished - 1976
Externally publishedYes

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Biotransformation
Carbohydrates
Protein-Restricted Diet
Pharmaceutical Preparations
Diet
Antipyrine
Theophylline
Half-Life
Dietary Carbohydrates
Proteins
Dietary Proteins
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Healthy Volunteers
Eating

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Interactions between nutritional factors and drug biotransformations in man. / Alvares, A. P.; Anderson, Karl; Conney, A. H.; Kappas, A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 73, No. 7, 1976, p. 2501-2504.

Research output: Contribution to journalArticle

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