Interference with the Function of Leukocyte Adhesion Molecules by Monoclonal Antibodies: A New Approach to Burn Injury

W. J. Mileski, R. Rothlien, P. Lipsky

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in bum wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalEuropean Journal of Pediatric Surgery
Volume4
Issue number4
DOIs
StatePublished - Aug 1994
Externally publishedYes

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Keywords

  • Burns
  • ICAM-1
  • Leukocyte

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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