Interference with the function of leukocyte adhesion molecules by monoclonal antibodies

A new approach to burn injury

William Mileski, R. Rothlien, P. Lipsky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in burn wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalEuropean Journal of Pediatric Surgery
Volume4
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Cell Adhesion Molecules
Monoclonal Antibodies
Wounds and Injuries
Leukocytes
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Interference with the function of leukocyte adhesion molecules by monoclonal antibodies : A new approach to burn injury. / Mileski, William; Rothlien, R.; Lipsky, P.

In: European Journal of Pediatric Surgery, Vol. 4, No. 4, 1994, p. 225-230.

Research output: Contribution to journalArticle

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