Interference with the Function of Leukocyte Adhesion Molecules by Monoclonal Antibodies: A New Approach to Burn Injury

W. J. Mileski; R. Rothlien; P. Lipsky

doi:10.1055/s-2008-1066110

Interference with the Function of Leukocyte Adhesion Molecules by Monoclonal Antibodies: A New Approach to Burn Injury

W. J. Mileski
, R. Rothlien
, P. Lipsky

Surgery

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in bum wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.

Original language	English (US)
Pages (from-to)	225-230
Number of pages	6
Journal	European Journal of Pediatric Surgery
Volume	4
Issue number	4
DOIs	https://doi.org/10.1055/s-2008-1066110
State	Published - Aug 1994

Keywords

Burns
ICAM-1
Leukocyte

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery

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10.1055/s-2008-1066110

Cite this

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title = "Interference with the Function of Leukocyte Adhesion Molecules by Monoclonal Antibodies: A New Approach to Burn Injury",

abstract = "Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in bum wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.",

keywords = "Burns, ICAM-1, Leukocyte",

author = "Mileski, \{W. J.\} and R. Rothlien and P. Lipsky",

year = "1994",

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T2 - A New Approach to Burn Injury

AU - Mileski, W. J.

AU - Rothlien, R.

AU - Lipsky, P.

PY - 1994/8

Y1 - 1994/8

N2 - Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in bum wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.

AB - Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in bum wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.

KW - Burns

KW - ICAM-1

KW - Leukocyte

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UR - https://www.scopus.com/pages/publications/0027931232#tab=citedBy

U2 - 10.1055/s-2008-1066110

DO - 10.1055/s-2008-1066110

M3 - Article

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AN - SCOPUS:0027931232

SN - 0939-7248

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JF - European Journal of Pediatric Surgery

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Interference with the Function of Leukocyte Adhesion Molecules by Monoclonal Antibodies: A New Approach to Burn Injury

Abstract

Keywords

ASJC Scopus subject areas

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