Interferon-β 1a and SARS Coronavirus Replication

Lisa E. Hensley, Elizabeth A. Fritz, Peter B. Jahrling, Christopher L. Karp, John W. Huggins, Thomas W. Geisbert

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon -β 1a potently inhibits SARS coronavirus replication in vitro.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalEmerging infectious diseases
Volume10
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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